Promoting Effect of Unilateral Nephrectomy on Urinary Bladder Carcinogenesis in Rats

• Published in: Cancer science Vol. 87; no. 11; pp. 1121 - 1124
• Main Authors: Saikawa, Shigeki, Kanamaru, Hiroshi, Li, Benyi, Matsukawa, Shigeru, Okada, Kenichiro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.1996; Japanese Cancer Association; John Wiley & Sons, Inc
• Subjects: Animals; Biological and medical sciences; Bladder; Bladder cancer; Butylhydroxybutylnitrosamine - toxicity; Carcinogenesis; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Chemical agents; Chemical carcinogenesis; Cocarcinogenesis; Drinking - drug effects; Hyperplasia; Male; Medical sciences; Nephrectomy; Nephrectomy - adverse effects; Promoter; Rats; Rats, Inbred F344; Tumors; Unilateral nephrectomy; Urinary bladder; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - etiology; Urinary Bladder Neoplasms - pathology; Urinary system disease; Rat; Nitrosamine; Tumor promotor; Rodentia; Malignant tumor; Urinary tract disease; Transitional cell carcinoma; Carcinogenesis; Carcinogen; Vertebrata; Experimental disease; Mammalia; Nephrectomy; Urinary bladder; Surgery; Animal; Unilateral; Bladder disease
• ISSN: 0910-5050; 1347-9032; 1349-7006; 1876-4673
• DOI: 10.1111/j.1349-7006.1996.tb03121.x

The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05%N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN administration significantly increased both the number and the volume of visible tumors per rat as compared with the sham‐operated group. Histological examination also revealed that the numbers of papillonodular hyperplasia and cancer per basement membrane were significantly increased by unilateral nephrectomy. The results imply a growth‐enhancing effect of unilateral nephrectomy on carcinogenesis of the rat bladder.