The 981C>T polymorphism in protein tyrosine phosphatase 1B is associated with decreased risk of coronary artery disease in Chinese Han population

• Published in: Atherosclerosis Vol. 218; no. 1; pp. 147 - 150
• Main Authors: Zhou, Xiang, Xu, Weiting, Chen, Jianchang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.2011
• Subjects: Aged; atherosclerosis; blood glucose; Blood Glucose - metabolism; blood serum; Body Mass Index; Cardiovascular; case-control studies; chemistry; China; confidence interval; Coronary artery disease; Coronary Artery Disease - diagnosis; Coronary Artery Disease - ethnology; Coronary Artery Disease - genetics; diagnosis; ethnology; Female; genetics; Genotype; Humans; Lipids; Lipids - chemistry; Male; metabolism; Middle Aged; Odds Ratio; patients; Polymorphism; Polymorphism, Genetic; Protein tyrosine phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics; protein-tyrosine-phosphatase; Risk; risk reduction; triacylglycerols; China; Protein tyrosine phosphatase 1B; Coronary artery disease; Polymorphism
• ISSN: 0021-9150; 1879-1484; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2011.05.021

The present study was designed to investigate the potential association between the 981C>T polymorphism in protein tyrosine phosphatase 1B (PTP-1B) and coronary artery disease (CAD). We conducted a hospital-based case–control study with 864 CAD patients and 1008 controls to explore the association between the PTP-1B 981C>T polymorphism and risk of CAD in Chinese Han population. Subjects with the variant genotypes (CT+TT) had a 52% decreased risk of CAD relative to CC carriers (adjusted odds ratio, 0.48; 95% confidence interval, 0.39–0.60). The 981C>T polymorphism was associated with a higher body mass index and serum triglyceride levels in both CAD patients and controls. Moreover, this polymorphism was found to be associated with a lower serum glucose levels in cases, but not in controls. Our study demonstrates that the PTP-1B 981C>T polymorphism is associated with decreased risk of CAD in Chinese Han population.