Synthetic applications of intramolecular thiol-ene "click" reactions

The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated "click" process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide r...

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Bibliographic Details
Published inMolecules Vol. 19; no. 11; pp. 19137 - 19151
Main Authors Scanlan, Eoin M, Corcé, Vincent, Malone, Aoife
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 19.11.2014
MDPI
Subjects
carbohydrate
Click Chemistry - methods
free radical
Free Radicals - chemistry
organic synthesis
peptide
Peptides, Cyclic - chemistry
Review
Sulfhydryl Compounds - chemistry
Thiosugars - chemistry
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Summary:The intermolecular thiol-ene reaction is emerging as a highly efficient; free-radical mediated "click" process with diverse applications in biofunctionalisation and materials science. The related intramolecular thiol-ene reactions offer significant potential for the preparation of a wide range of sulphur containing heterocycles including synthetic therapeutics such as cyclic peptides and thiosugars. Herein, we review recent advances in intramolecular thiyl-radical mediated reactions and their applications for synthetic and medicinal chemistry.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules191119137