Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections

Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A...

Full description

Saved in:
Bibliographic Details
Published inEmerging microbes & infections Vol. 9; no. 1; pp. 535 - 538
Main Authors Elbediwi, Mohammed, Pan, Hang, Biswas, Silpak, Li, Yan, Yue, Min
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2020
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
antimicrobial resistance
Colistin - pharmacology
colistin resistance
Drug Resistance, Bacterial
Humans
Letter
mcr-1
Salmonella
Salmonella enterica - drug effects
Salmonella enterica - isolation & purification
Salmonella Infections - microbiology
Salmonella Newport
seafood
seafood
colistin resistance
Salmonella Newport
antimicrobial resistance
mcr-1
Online AccessGet full text

Cover

More Information
Summary:Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A retrospective study of 287 S. Newport clinical isolates collected during 1997-2018 was undertaken for characterization of AR profiles using the micro-dilution assay. We found a recent emergence of colistin resistance in four Chinese clinical isolates, including mcr-1-positive isolates. Importantly, phylogenomic and microbiological investigations indicate multiple independent clonal transmission of colistin-resistant S. Newport isolates of different seafood origins. Our study highlights potential reservoirs for transmission of colistin resistance and suggests that the global food supply chain may facilitate this dissemination.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 14
content type line 23
Supplemental data for this article can be accessed at https://doi.org/10.1080/22221751.2020.1733439
These authors contributed equally to this work.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1733439