Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats
Knowledge of genetic polymorphisms of cytochrome P450 (CYP), the most important xenobiotic metabolizing enzyme, is very limited in cats. Preliminarily, we investigated genetic polymorphisms in CYP2A13, one of the major CYP isoforms in the liver and lung. Four synonymous and three non-synonymous poly...
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Published in | Journal of Veterinary Medical Science Vol. 81; no. 7; pp. 983 - 985 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Japan
JAPANESE SOCIETY OF VETERINARY SCIENCE
01.07.2019
Japan Science and Technology Agency The Japanese Society of Veterinary Science |
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Abstract | Knowledge of genetic polymorphisms of cytochrome P450 (CYP), the most important xenobiotic metabolizing enzyme, is very limited in cats. Preliminarily, we investigated genetic polymorphisms in CYP2A13, one of the major CYP isoforms in the liver and lung. Four synonymous and three non-synonymous polymorphic variants were identified in feline CYP2A13 in domestic cats in Japan, without an obvious major type. Metabolic parameters, Km and Vmax, of coumarin hydroxylation of CYP2A13 were shown to range within two times for the identified non-synonymous polymorphic variants by using heterologous coexpression system in Escherichia coli. The results confirmed the polymorphic nature of CYP2A13 as a basis for effective application of medicines and prevention of adverse reactions in treatment of domestic cats. |
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AbstractList | Knowledge of genetic polymorphisms of cytochrome P450 (CYP), the most important xenobiotic metabolizing enzyme, is very limited in cats. Preliminarily, we investigated genetic polymorphisms in CYP2A13, one of the major CYP isoforms in the liver and lung. Four synonymous and three non-synonymous polymorphic variants were identified in feline CYP2A13 in domestic cats in Japan, without an obvious major type. Metabolic parameters, Km and Vmax, of coumarin hydroxylation of CYP2A13 were shown to range within two times for the identified non-synonymous polymorphic variants by using heterologous coexpression system in Escherichia coli. The results confirmed the polymorphic nature of CYP2A13 as a basis for effective application of medicines and prevention of adverse reactions in treatment of domestic cats. Knowledge of genetic polymorphisms of cytochrome P450 (CYP), the most important xenobiotic metabolizing enzyme, is very limited in cats. Preliminarily, we investigated genetic polymorphisms in CYP2A13, one of the major CYP isoforms in the liver and lung. Four synonymous and three non-synonymous polymorphic variants were identified in feline CYP2A13 in domestic cats in Japan, without an obvious major type. Metabolic parameters, Km and Vmax, of coumarin hydroxylation of CYP2A13 were shown to range within two times for the identified non-synonymous polymorphic variants by using heterologous coexpression system in Escherichia coli . The results confirmed the polymorphic nature of CYP2A13 as a basis for effective application of medicines and prevention of adverse reactions in treatment of domestic cats. |
Author | TERAOKA, Hiroki SUGIYAMA, Souta KITAZAWA, Takio UNO, Yasuhiro AMANO, Tomoko |
Author_xml | – sequence: 1 fullname: SUGIYAMA, Souta organization: School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan – sequence: 2 fullname: UNO, Yasuhiro organization: Shin Nippon Biomedical Laboratories, Ltd., Kainan, Wakayama 642-0017, Japan – sequence: 3 fullname: AMANO, Tomoko organization: College of Agriculture, Food and Environment Sciences, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan – sequence: 4 fullname: KITAZAWA, Takio organization: School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan – sequence: 5 fullname: TERAOKA, Hiroki organization: School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan |
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Cites_doi | 10.1016/S0009-2797(97)00068-9 10.1371/journal.pone.0082562 10.3109/00498254.2014.998322 10.1016/j.cvsm.2013.05.001 10.1080/00498254.2016.1257172 10.1292/jvms.18-0692 10.1093/carcin/bgi301 10.1080/03602530902843483 |
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SubjectTerms | Animals Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Cats Cats - genetics Cats - metabolism Coumarin Coumarins - metabolism Cytochrome Cytochrome P450 domestic cat Female Genetic diversity Genetic Variation Hydroxylation Isoforms Liver - enzymology Lungs Male Metabolism polymorphism Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Analysis, DNA Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism Toxicology xenobiotic |
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Title | Genetic diversity of cytochrome P450 2A with different metabolic activities in domestic cats |
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