SnapShot: Medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification has id...

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Bibliographic Details
Published inCancer cell Vol. 26; no. 6; pp. 940 - 940.e1
Main Authors Rusert, Jessica M., Wu, Xiaochong, Eberhart, Charles G., Taylor, Michael D., Wechsler-Reya, Robert J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.12.2014
Subjects
Animals
Cerebellar Neoplasms - genetics
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - therapy
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Humans
Medulloblastoma - genetics
Medulloblastoma - pathology
Medulloblastoma - therapy
Mice
Neoplasms, Experimental
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Summary:Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification has identified four major subgroups and provides greater opportunity for developing targeted therapies more successful than current conventional therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2014.11.015