Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

• Published in: Drug delivery Vol. 27; no. 1; pp. 1741 - 1749
• Main Authors: Liao, Rongqiang, Liu, Ying, Lv, Pin, Wu, Di, Xu, Meiling, Zheng, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Aqueous solutions; Bioavailability; Biocompatibility; Cyclodextrin; drug carrier; Drug delivery systems; poly(ε-lysine); Polymers; scutellarin; Severe acute respiratory syndrome coronavirus 2; Spectrum analysis; Cyclodextrin; poly(ε-lysine); drug carrier; scutellarin
• ISSN: 1071-7544; 1521-0464
• DOI: 10.1080/10717544.2020.1856223

A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:ε-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, 1 H and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:ε-PL-CD was significantly improved compared with SCU:β-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:ε-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for ε-PL-CD as a drug carrier material.