Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system

• Published in: Materials Science & Engineering C Vol. 54; pp. 252 - 261
• Main Authors: Oliveira, Michele F., Suarez, Diego, Rocha, Júlio Cézar Barbosa, de Carvalho Teixeira, Alvaro Vianna Novaes, Cortés, Maria E., De Sousa, Frederico B., Sinisterra, Rubén D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: Biocompatible Materials - chemistry; Cells, Cultured; Cells, Immobilized; Cellulose - chemistry; Controlled release; Cyclodextrins - chemistry; Drug delivery system; Drug delivery systems; Drug Delivery Systems - methods; Electrospinning; Fibroblasts - cytology; Fibroblasts - drug effects; Gingiva - cytology; Gingiva - drug effects; Humans; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Materials science; Microscopy, Electron, Transmission; Modulation; Nanofibers; Nanofibers - chemistry; Poly-cyclodextrin; Polymeric nanofibers; Polymethacrylic Acids - chemistry; PRoP; Propranolol; Reduction; Electrospinning; Poly-cyclodextrin; Propranolol; Drug delivery system; Polymeric nanofibers
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.04.042

Herein, we used an electrospinning process to develop highly efficacious and hydrophobic coaxial nanofibers based on poly-cyclodextrin (polyCD) associated with poly(methacrylic acid) (PMAA) that combines polymeric and supramolecular features for modulating the release of the hydrophilic drug, propranolol hydrochloride (PROP). For this purpose, polyCD was synthesized and characterized, and its biocompatibility was assessed using fibroblast cytotoxicity tests. Moreover, the interactions between the guest PROP molecule and both polyCD and βCD were found to be spontaneous. Subsequently, PROP was encapsulated in uniaxial and coaxial polyCD/PMAA nanofibers. A lower PROP burst effect (reduction of approximately 50%) and higher modulation were observed from the coaxial than from the uniaxial fibers. Thus, the coaxial nanofibers could potentially be a useful strategy for developing a controlled release system for hydrophilic molecules. •Nanofibers were obtained by electrospinning using PMAA, polyCD and PROP.•PolyCD is a biocompatible polymer presenting spontaneous interactions with PROP.•Coaxial fibers exhibited a lower burst effect and higher drug modulation.•We report an useful strategy to delivery hydrophilic drugs.