Decoding internally generated transitions of conscious contents in the prefrontal cortex without subjective reports

• Published in: Nature communications Vol. 13; no. 1; p. 1535
• Main Authors: Kapoor, Vishal, Dwarakanath, Abhilash, Safavi, Shervin, Werner, Joachim, Besserve, Michel, Panagiotaropoulos, Theofanis I, Logothetis, Nikos K
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 22.03.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Animals; Consciousness; Consciousness - physiology; Cortex (somatosensory); Debates; Macaca mulatta; Monkeys & apes; Perception; Photic Stimulation; Populations; Prefrontal cortex; Prefrontal Cortex - physiology; Signal processing; Visual perception; Visual Perception - physiology; Visual stimuli
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-022-28897-2

A major debate about the neural correlates of conscious perception concerns its cortical organization, namely, whether it includes the prefrontal cortex (PFC), which mediates executive functions, or it is constrained within posterior cortices. It has been suggested that PFC activity during paradigms investigating conscious perception is conflated with post-perceptual processes associated with reporting the contents of consciousness or feedforward signals originating from exogenous stimulus manipulations and relayed via posterior cortical areas. We addressed this debate by simultaneously probing neuronal populations in the rhesus macaque (Macaca mulatta) PFC during a no-report paradigm, capable of instigating internally generated transitions in conscious perception, without changes in visual stimulation. We find that feature-selective prefrontal neurons are modulated concomitantly with subjective perception and perceptual suppression of their preferred stimulus during both externally induced and internally generated changes in conscious perception. Importantly, this enables reliable single-trial, population decoding of conscious contents. Control experiments confirm significant decoding of stimulus contents, even when oculomotor responses, used for inferring perception, are suppressed. These findings suggest that internally generated changes in the contents of conscious visual perception are reliably reflected within the activity of prefrontal populations in the absence of volitional reports or changes in sensory input.