Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model

Highlights • The efficacy of neuraxial glucocorticoids for neuropathic pain is subject to debate. • Glucocorticoids act mainly through their receptor (GR). • Spinal nerve ligation increases spinal GR protein levels but not GR mRNA levels. • After intrathecal glucocorticoid treatment only spinal GR m...

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Published inScandinavian journal of pain Vol. 16; no. 1; pp. 1 - 9
Main Authors Rijsdijk, M, Agalave, N.M, van Wijck, A.J.M, Kalkman, C.J, Ramachandran, R, Baharpoor, A, Svensson, C.I, Yaksh, T.L
Format Journal Article
LanguageEnglish
Published Germany Elsevier B.V 01.07.2017
De Gruyter
Subjects
Animals
Disease Models, Animal
Glucocorticoid receptor
Glucocorticoids - pharmacology
Hyperalgesia
Injections, Spinal
Internal Medicine
Intrathecal
Ligation
Male
Mechanical allodynia
Medicin och hälsovetenskap
Methylprednisolone acetate
Methylprednisolone Acetate - pharmacology
Neuralgia - metabolism
Pain Medicine
Rats
Rats, Sprague-Dawley
Receptors, Glucocorticoid
RNA, Messenger - metabolism
Spinal nerve ligation
Spinal Nerves - drug effects
Spinal nerve ligation
Rats
Methylprednisolone acetate
Intrathecal
Glucocorticoid receptor
Mechanical allodynia
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Summary:Highlights • The efficacy of neuraxial glucocorticoids for neuropathic pain is subject to debate. • Glucocorticoids act mainly through their receptor (GR). • Spinal nerve ligation increases spinal GR protein levels but not GR mRNA levels. • After intrathecal glucocorticoid treatment only spinal GR mRNA decreases. • This does not result in decreased ligation-induced mechanical hypersensitivity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1877-8860
1877-8879
1877-8879
DOI:10.1016/j.sjpain.2016.12.008