Transgenerational epigenetic inheritance: how important is it?

Much attention has been given to the idea of transgenerational epigenetic inheritance, but fundamental questions remain regarding how much takes place and the impact that this might have on organisms. We asked five leading researchers in this area--working on a range of model organisms and in human...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Genetics Vol. 14; no. 3; pp. 228 - 235
Main Authors Grossniklaus, Ueli, Kelly, William G, Kelly, Bill, Ferguson-Smith, Anne C, Pembrey, Marcus, Lindquist, Susan
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.03.2013
Subjects
Animal models in research
Animals
Disease Models, Animal
DNA methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Epigenomics
Genes
Heredity
Humans
Inheritance Patterns - genetics
United Kingdom
Online AccessGet full text

Cover

More Information
Summary:Much attention has been given to the idea of transgenerational epigenetic inheritance, but fundamental questions remain regarding how much takes place and the impact that this might have on organisms. We asked five leading researchers in this area--working on a range of model organisms and in human disease--for their views on these topics. Their responses highlight the mixture of excitement and caution that surrounds transgenerational epigenetic inheritance and the wide gulf between species in terms of our knowledge of the mechanisms that may be involved.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1471-0056
1471-0064
DOI:10.1038/nrg3435