Blood-based diagnostics of traumatic brain injuries

Traumatic brain injury is a major health and socioeconomic problem that affects all societies. However, traditional approaches to the classification of clinical severity are the subject of debate and are being supplemented with structural and functional neuroimaging, as the need for biomarkers that...

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Bibliographic Details
Published inExpert review of molecular diagnostics Vol. 11; no. 1; pp. 65 - 78
Main Authors Mondello, Stefania, Muller, Uwe, Jeromin, Andreas, Streeter, Jackson, Hayes, Ronald L, Wang, Kevin KW
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2011
Expert Reviews Ltd
Informa Healthcare
Subjects
Biological markers
biomarkers
Biomarkers - blood
Brain
Brain Chemistry
Brain Injuries - blood
Brain Injuries - diagnosis
clinical management
Clinical Trials as Topic
diagnostics
ELISA
Enzyme-Linked Immunosorbent Assay
Humans
Immunoassay
Injuries
Molecular Diagnostic Techniques - methods
Molecular Diagnostic Techniques - trends
Neuroimaging
Physiological aspects
Point-of-Care Systems
prognostics
Proteome - analysis
proteomics
traumatic brain injury
United States
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Summary:Traumatic brain injury is a major health and socioeconomic problem that affects all societies. However, traditional approaches to the classification of clinical severity are the subject of debate and are being supplemented with structural and functional neuroimaging, as the need for biomarkers that reflect elements of the pathogenetic process is widely recognized. Basic science research and developments in the field of proteomics have greatly advanced our knowledge of the mechanisms involved in damage and have led to the discovery and rapid detection of new biomarkers that were not available previously. However, translating this research for patients' benefits remains a challenge. In this article, we summarize new developments, current knowledge and controversies, focusing on the potential role of these biomarkers as diagnostic, prognostic and monitoring tools of brain-injured patients.
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These authors contributed equally to this article.
ISSN:1473-7159
1744-8352
1744-8352
DOI:10.1586/erm.10.104