Akt as a Victim, Villain and Potential Hero in Parkinson’s Disease Pathophysiology and Treatment

There are two major purposes of this essay. The first is to summarize existing evidence that irrespective of the initiating causes, neuron death and degeneration in Parkinson’s disease (PD) are due to the common feature of failure of signaling by Akt, a kinase involved in neuron survival and mainten...

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Bibliographic Details
Published inCellular and molecular neurobiology Vol. 31; no. 7; pp. 969 - 978
Main Authors Greene, Lloyd A., Levy, Oren, Malagelada, Cristina
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.10.2011
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Death - physiology
Humans
Neurobiology
Neurons - cytology
Neurons - pathology
Neurons - physiology
Neurosciences
Original Paper
Parkinson Disease - genetics
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction - physiology
Neuroprotection
Akt
Neurodegeneration
Parkinson’s disease
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Summary:There are two major purposes of this essay. The first is to summarize existing evidence that irrespective of the initiating causes, neuron death and degeneration in Parkinson’s disease (PD) are due to the common feature of failure of signaling by Akt, a kinase involved in neuron survival and maintenance of synaptic contacts. The second is to consider possible means by which such a failure of Akt signaling might be benignly prevented or reversed in neurons affected by PD, so as to treat PD symptoms, block disease progression, and potentially, promote recovery.
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ISSN:0272-4340
1573-6830
1573-6830
DOI:10.1007/s10571-011-9671-8