EAGER: efficient ancient genome reconstruction

The automated reconstruction of genome sequences in ancient genome analysis is a multifaceted process. Here we introduce EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets. EAGER provides features to preprocess, map, authenticate, and assess the...

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Bibliographic Details
Published inGenome Biology Vol. 17; no. 1; p. 60
Main Authors Peltzer, Alexander, Jäger, Günter, Herbig, Alexander, Seitz, Alexander, Kniep, Christian, Krause, Johannes, Nieselt, Kay
Format Journal Article
LanguageEnglish
Published England BioMed Central 31.03.2016
Subjects
Archaeology
Bioinformatics
Chromosome Mapping - methods
Deoxyribonucleic acid
DNA
Fossils
Genome
Genomes
Genotypes
Linux
Methods
Mitochondrial DNA
Researchers
Sequence Analysis, DNA - methods
Software
User interface
Workflow
aDNA analysis
Genome reconstruction
aDNA
Bioinformatics
Authentication
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Summary:The automated reconstruction of genome sequences in ancient genome analysis is a multifaceted process. Here we introduce EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets. EAGER provides features to preprocess, map, authenticate, and assess the quality of ancient DNA samples. Additionally, EAGER comprises tools to genotype samples to discover, filter, and analyze variants. EAGER encompasses both state-of-the-art tools for each step as well as new complementary tools tailored for ancient DNA data within a single integrated solution in an easily accessible format.
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ISSN:1474-760X
1474-7596
1474-760X
DOI:10.1186/s13059-016-0918-z