Phases I–III Clinical Trials Using Adult Stem Cells

First randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. Nevertheless, some trials have shown that conflicting results and uncertainties remain in the case...

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Bibliographic Details
Published inStem cells international Vol. 2010; no. 2010; pp. 1 - 12
Main Authors Sanz-Ruiz, Ricardo, Gutiérrez Ibañes, Enrique, Arranz, Adolfo Villa, Fernández Santos, María Eugenia, Fernández, Pedro L. Sánchez, Fernández-Avilés, Francisco
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2010
SAGE-Hindawi Access to Research
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Cardiomyopathy
Care and treatment
Diagnosis
Heart diseases
Heart ventricle, Left
Physiological aspects
Review
Stem cells
Spain
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Summary:First randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. Nevertheless, some trials have shown that conflicting results and uncertainties remain in the case of mechanisms of action and possible ways to improve clinical impact of stem cells in cardiac repair. In this paper we will examine the evidence available, analyze the main phase I and II randomized clinical trials and their limitations, discuss the key points in the design of future trials, and depict new directions of research in this fascinating field.
Bibliography:ObjectType-Article-1
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Academic Editor: Louis Casteilla
ISSN:1687-966X
0000-0002
1687-9678
1687-9678
DOI:10.4061/2010/579142