History of uterine leiomyoma and risk of endometrial cancer in black women
Background Previous studies have found an association between uterine leiomyomata (UL) and uterine malignancies. This relation has not been studied in black women, who are disproportionately affected by UL. Methods We investigated prospectively the association between self-reported physician-diagnos...
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Published in | Cancer causes & control Vol. 27; no. 4; pp. 545 - 552 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer Science + Business Media
01.04.2016
Springer International Publishing Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Previous studies have found an association between uterine leiomyomata (UL) and uterine malignancies. This relation has not been studied in black women, who are disproportionately affected by UL.
Methods
We investigated prospectively the association between self-reported physician-diagnosed UL and endometrial cancer in the Black Women’s Health Study. During 1995–2013, 47,267 participants with intact uteri completed biennial health questionnaires. Reports of endometrial cancer were confirmed by pathology data from medical records and cancer registries. Cox regression was used to derive incidence rate ratios (IRR) and 95 % confidence intervals (CI).
Results
There were 300 incident endometrial cancer cases during 689,546 person-years of follow-up. In multivariable models, UL history was associated with a 42 % greater incidence of endometrial cancer compared with no such history (95 % CI 1.12–1.80). IRRs for cancer diagnosed 0–2, 3–9, and ≥10 years after UL diagnosis were 3.20 (95 % CI 2.06–4.98), 0.95 (95 % CI 0.60–1.52), and 1.35 (95 % CI 1.03–1.77), respectively. Stronger overall associations between UL history and endometrial cancer were observed for later stages at cancer diagnosis (IRR = 2.25, 95 % CI 1.09–4.63) and type II/III cancers (IRR = 3.13, 95 % CI 1.64–5.99).
Conclusions
In this large cohort of black women, a history of UL was positively associated with endometrial cancer, particularly type II/III tumors. The strongest association was observed for cancer diagnosed within 2 years of UL diagnosis, a finding that might be explained by greater surveillance of women with UL or misdiagnosis of cancer as UL. However, an association was also observed for cancer reported ≥10 years after UL diagnosis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Slone Epidemiology Center at Boston University, Boston, Massachusetts (Todd R. Sponholtz, Julie R. Palmer, Lynn Rosenberg, Lauren A. Wise); Boston University School of Public Health, Boston, Massachusetts (Todd R. Sponholtz, Julie R. Palmer, Lynn Rosenberg, Lauren A. Wise, Michael P. LaValley), Lombardi Cancer Center, Georgetown University, Washington, DC (Lucile L Adams-Campbell), and Boston University School of Medicine, Boston, Massachusetts (Wendy Kuohung). |
ISSN: | 0957-5243 1573-7225 |
DOI: | 10.1007/s10552-016-0728-3 |