Guidance molecules in lung cancer

Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer devel...

Full description

Saved in:
Bibliographic Details
Published inCell adhesion & migration Vol. 4; no. 1; pp. 130 - 145
Main Authors Nasarre, Patrick, Potiron, Vincent, Drabkin, Harry, Roche, Joëlle
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2010
Landes Bioscience
Subjects
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Signal Transducing - metabolism
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Humans
Landes
Life Sciences
Lung
Lung - embryology
Lung - metabolism
Lung Neoplasms
Lung Neoplasms - metabolism
Lung Neoplasms - therapy
Organogenesis
Proteins
Signal Transduction
Special Focus: Lung Cancers
Online AccessGet full text

Cover

More Information
Summary:Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule families and their corresponding receptors are described, including the semaphorins/neuropilins/plexins, ephrins and Eph receptors, netrin/DCC/UNC5, Slit/Robo and Notch/Delta. In addition, the possibility to target these molecules as a therapeutic approach in cancer is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMCID: PMC2852570
ISSN:1933-6918
1933-6926
DOI:10.4161/cam.4.1.10882