Serum total antioxidant capacity in oral carcinoma patients

Context: Oxidative stress is a major determinant in carcinogenesis and serum total antioxidant capacity (TAC) indirectly reflects the level of oxidative stress. Although oral cancer is the third most frequent cancer in Indian population, there are no standard noninvasive marker for early detection a...

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Bibliographic Details
Published inPharmacognosy research Vol. 7; no. 2; pp. 184 - 187
Main Authors Rathan Shetty, K, Kali, Arunava, Rachan Shetty, K
Format Journal Article
LanguageEnglish
Published India Medknow Publications Pvt Ltd 01.04.2015
Medknow Publications and Media Pvt. Ltd
Phcog.net
Medknow Publications & Media Pvt Ltd
Subjects
Abdomen
Antioxidants
Antioxidants (Nutrients)
Breast cancer
Cancer patients
Cancer therapies
Deoxyribonucleic acid
DNA
DNA damage
Free radicals
Laboratories
Mortality
Nitrogen
Oral cancer
Original
Otolaryngology
Pathogenesis
Postoperative period
Radiation therapy
Smoking
India
Cancer marker
total antioxidant capacity
oral cancer
squamous cell carcinoma
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Summary:Context: Oxidative stress is a major determinant in carcinogenesis and serum total antioxidant capacity (TAC) indirectly reflects the level of oxidative stress. Although oral cancer is the third most frequent cancer in Indian population, there are no standard noninvasive marker for early detection and monitoring therapeutic response in oral cancer patients. Aims: This study was carried out to investigate implications of serum TAC in oral cancer by evaluating pre- and post-operative levels in oral cancer patients. Settings and Designs: It was a prospective single blinded study. Subjects and Methods: Serum TAC was measured using ferric-reducing antioxidant power assay. Pre- and post-operative values were estimated and compared in 30 oral cancer patients who underwent surgery. Statistical Analysis Used: Paired t-test was used to compare pre- and post-operative values. Results: Compared to the normal value, both pre- and post-operative serum TAC were significantly low in oral cancer patients. However, there was no statistically significant difference between pre- and postoperative levels. Conclusions: In this study, low mean serum TAC was detected in oral cancer patients. However, its diagnostic and prognostic significance in oral cancer needs further investigation.
ISSN:0974-8490
0976-4836
0974-8490
DOI:10.4103/0974-8490.150513