A Novel Strategy for Rapid Fluorescence Detection of FluB and SARS-CoV-2

Undoubtedly, SARS-CoV-2 has caused an outbreak of pneumonia that evolved into a worldwide pandemic. The confusion of early symptoms of the SARS-CoV-2 infection with other respiratory virus infections made it very difficult to block its spread, leading to the expansion of the outbreak and an unreason...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 5; p. 2104
Main Authors Yang, Zhijin, Xue, Zhiwei, Zheng, Kejie, Zhang, Yule, Sui, Guorong, Yang, Haima, Zhuang, Songlin, Zheng, Lulu, Zhang, Dawei
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.02.2023
MDPI
Subjects
Antibodies
Antigens
Binding sites
China
COVID-19
Epidemics
FluB
Fluorescence
Health aspects
Humans
immunochromatographic test strip
Immunofluorescence
Infections
Influenza
Limit of Detection
Microspheres
Outbreaks
Portable equipment
Proteins
Quantum dots
Quantum Dots - chemistry
rapid fluorescence detection
Resource allocation
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Smartphones
Ultraviolet radiation
Virus diseases
Viruses
China
FluB
SARS-CoV-2
immunochromatographic test strip
rapid fluorescence detection
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Summary:Undoubtedly, SARS-CoV-2 has caused an outbreak of pneumonia that evolved into a worldwide pandemic. The confusion of early symptoms of the SARS-CoV-2 infection with other respiratory virus infections made it very difficult to block its spread, leading to the expansion of the outbreak and an unreasonable demand for medical resource allocation. The traditional immunochromatographic test strip (ICTS) can detect one analyte with one sample. Herein, this study presents a novel strategy for the simultaneous rapid detection of FluB/SARS-CoV-2, including quantum dot fluorescent microspheres (QDFM) ICTS and a supporting device. The ICTS could be applied to realize simultaneous detection of FluB and SARS-CoV-2 with one test in a short time. A device supporting FluB/SARS-CoV-2 QDFM ICTS was designed and had the characteristics of being safe, portable, low-cost, relatively stable, and easy to use, ensuring the device could replace the immunofluorescence analyzer in cases where there is no need for quantification. This device does not need to be operated by professional and technical personnel and has commercial application potential.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28052104