The impact of visceral adipose tissue and high–molecular weight adiponectin on cardio-ankle vascular index in asymptomatic Japanese subjects

• Published in: Metabolism, clinical and experimental Vol. 58; no. 7; pp. 1023 - 1029
• Main Authors: Ohashi, Norihiko, Ito, Chikako, Fujikawa, Rumi, Yamamoto, Hideya, Kihara, Yasuki, Kohno, Nobuoki
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2009; Elsevier
• Subjects: Adiponectin - physiology; Adult; Aged; Ankle Brachial Index; Aorta - physiology; Biological and medical sciences; Blood Glucose - metabolism; Blood Pressure - physiology; Body Mass Index; C-Reactive Protein - metabolism; Cholesterol - blood; Endocrinology & Metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glycated Hemoglobin A - metabolism; Humans; Insulin - blood; Intra-Abdominal Fat - physiology; Japan; Male; Middle Aged; ROC Curve; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Waist Circumference - physiology; Young Adult; Human; Adipose tissue; Blood vessel; Asymptomatic; Circulatory system; Japanese; Molecular mass; Endocrinology; Adiponectin
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2009.03.005

Abstract Few studies addressed the relation of visceral adiposity and high–molecular weight (HMW) adiponectin to arterial stiffness. We investigated the impact of visceral adipose tissue (VAT) and HMW adiponectin on cardio-ankle vascular index (CAVI) in asymptomatic Japanese subjects. We studied 487 consecutive subjects (271 men and 216 women) who underwent general health examination between October 2005 and May 2008. The abdominal, visceral, and subcutaneous adipose tissue areas were determined by low-dose x-ray computed tomography. Serum levels of total and HMW adiponectin were measured using the enzyme-linked immunosorbent assay system based on a monoclonal antibody to humans. Cardio-ankle vascular index was positively correlated with VAT area and negatively correlated with HMW adiponectin levels. We also found the positive association of the number of metabolic syndrome components with CAVI in both sexes. A stepwise multiple regression analysis revealed that age, VAT area, serum HMW adiponectin levels, and homeostasis model assessment of insulin resistance were independent determinants of CAVI. Receiver operating characteristic analyses demonstrated that the predictive value of the VAT area for the extent of CAVI (mild: <25th percentile vs severe: >75th percentile) exceeded that of total or HMW adiponectin levels in both sexes. In conclusion, increased CAVI is associated with both amounts of VAT measured by computed tomography and serum HMW adiponectin levels in asymptomatic Japanese subjects. Receiver operating characteristic analysis indicates that the VAT area is a lot better predictor of arterial stiffness than adiponectin levels.