Prevalent distribution and survival outcome of HPV infection in patients with early-stage cervical cancer in Hangzhou, China

• Published in: BMC infectious diseases Vol. 22; no. 1; p. 941
• Main Authors: Xu, Xiaoxian, Feng, Tao, Li, Dan, Lou, Hanmei, Lan, Huiyin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.12.2022; BioMed Central; BMC
• Subjects: Antigens; Cancer; Carcinogens; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - genetics; Cervical cancer; Chi-square test; China - epidemiology; Complications and side effects; Female; Genotype; Genotypes; Health risks; High‐risk human papillomavirus (HR‐HPV); Human papillomavirus; Humans; Infections; Lymph nodes; Lymphatic Metastasis; Medical prognosis; Medical records; Metastases; Methods; Overall survival (OS); Papillomaviridae - genetics; Papillomavirus infections; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Prevalence; Prevalence studies (Epidemiology); Prevention; Prognosis; Regression analysis; Retrospective Studies; Risk factors; Sexually transmitted diseases; Squamous cell carcinoma; Surgery; Survival; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Vaccines; Viruses; China; United States > US; Genotype; Overall survival (OS); Prevalence; Cervical cancer; High‐risk human papillomavirus (HR‐HPV)
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-022-07888-0

To describe the prevalent distribution of human papilloma virus (HPV) infection in patients with early-stage cervical squamous cell carcinoma (CSCC). To provide data on high-risk HPV (HR-HPV) infection and other clinicopathological factors for their correlations with the survival of CSCC patients. A total of 1425 patients with FIGO stages IA to IIA CSCC who underwent radical surgery between September 2008 and December 2012 were enrolled in the study. The prevalent distribution of HPV infection with different patient characteristics and survivals were analyzed with or without propensity score matching (PSM). The overall infection rate of HPV was 84.3%, including 13 carcinogenic HR-HPV genotypes and 8 low-risk HPV genotypes with infection rates of 82.6% and 5.8%, respectively. The distribution of HPV infection were proportional in patients with either different age groups or different FIGO stages. HPV16 was the dominant subtype with an infection rate of 65.1%, followed by the other top four subtypesHPV58 (8.7%), 18 (7.7%) and 52 (4.5%). χ analysis revealed that increased preoperative serum squamous cell carcinoma antigen levels and lymphovascular space invasion (LVSI) were statistically associated with HPV status. However, regression analyses indicated that only deep stromal invasion, LVSI and lymph node metastasis were independent prognostic factors on 5-year overall survival (OS), but not HR-HPV infection status even in the second exploratory analysis (P = 0.939) based on the PSM applied to reduce selection bias. This study provided baseline data on the prevalence characteristics of HPV infections in patients with early-stage CSCC, and HR-HPV infection was not a prognosticator of 5-year OS, other than FIGO stage, LVSI and lymph node metastasis.