Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis
We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7)...
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| Published in | Respiratory physiology & neurobiology Vol. 198; pp. 13 - 19 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.07.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1569-9048 1878-1519 1878-1519 |
| DOI | 10.1016/j.resp.2014.03.013 |
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| Abstract | We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7) and healthy subjects (n=6). In AR patients, cough frequency increased pronouncedly from 0.10±0.07 before to 2.37±0.73 during, and 1.80±0.79coughs/min for the first 8min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways. |
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| AbstractList | We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7) and healthy subjects (n=6). In AR patients, cough frequency increased pronouncedly from 0.10±0.07 before to 2.37±0.73 during, and 1.80±0.79coughs/min for the first 8min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways. Abstract We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4 min of humidified hot air (HA; 49 °C) and room air (RA; 21 °C) were compared between AR patients ( n = 7) and healthy subjects ( n = 6). In AR patients, cough frequency increased pronouncedly from 0.10 ± 0.07 before to 2.37 ± 0.73 during, and 1.80 ± 0.79 coughs/min for the first 8 min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways. We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4 minutes of humidified hot air (HA; 49 °C) and room air (RA: 21 °C) were compared between AR patients (n=7) and healthy subjects (n=6). In AR patients, cough frequency increased pronouncedly from 0.10±0.07 before to 2.37±0.73 during, and 1.80±0.79 coughs/min for the first 8 minutes after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways. We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7) and healthy subjects (n=6). In AR patients, cough frequency increased pronouncedly from 0.10±0.07 before to 2.37±0.73 during, and 1.80±0.79coughs/min for the first 8min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways.We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7) and healthy subjects (n=6). In AR patients, cough frequency increased pronouncedly from 0.10±0.07 before to 2.37±0.73 during, and 1.80±0.79coughs/min for the first 8min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways. |
| Author | Hayes, Don Lee, Lu-Yuan Khosravi, Mehdi Collins, Paul B. Lin, Ruei-Lung Smith, Jaclyn A. |
| AuthorAffiliation | e Center for Respiratory and Allergy, University of Manchester, Manchester, Southmoor Road, Manchester M23 9LT, United Kingdom c Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States d Departments of Pediatrics and Internal Medicine, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, United States a Department of Internal Medicine, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States b Pulmonary Function Laboratory, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States |
| AuthorAffiliation_xml | – name: b Pulmonary Function Laboratory, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States – name: d Departments of Pediatrics and Internal Medicine, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, United States – name: a Department of Internal Medicine, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States – name: e Center for Respiratory and Allergy, University of Manchester, Manchester, Southmoor Road, Manchester M23 9LT, United Kingdom – name: c Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States |
| Author_xml | – sequence: 1 givenname: Mehdi surname: Khosravi fullname: Khosravi, Mehdi organization: Department of Internal Medicine, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States – sequence: 2 givenname: Paul B. surname: Collins fullname: Collins, Paul B. organization: Pulmonary Function Laboratory, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States – sequence: 3 givenname: Ruei-Lung surname: Lin fullname: Lin, Ruei-Lung organization: Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States – sequence: 4 givenname: Don surname: Hayes fullname: Hayes, Don organization: Departments of Pediatrics and Internal Medicine, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, United States – sequence: 5 givenname: Jaclyn A. surname: Smith fullname: Smith, Jaclyn A. organization: Center for Respiratory and Allergy, University of Manchester, Manchester, Southmoor Road, Manchester M23 9LT, United Kingdom – sequence: 6 givenname: Lu-Yuan surname: Lee fullname: Lee, Lu-Yuan email: lylee@uky.edu, lylee@email.uky.edu organization: Department of Physiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY, 40536, United States |
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| Copyright | 2014 Elsevier B.V. Elsevier B.V. Copyright © 2014 Elsevier B.V. All rights reserved. 2014 Elsevier B.V. All rights reserved. 2014 |
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| Snippet | We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40%... Abstract We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic... |
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| SubjectTerms | Adult Air Airway irritation Airway Resistance Allergic rhinitis Carbon Dioxide - metabolism Cough Female Forced Expiratory Volume Hand Strength Hot Temperature - adverse effects Humans Humidity - adverse effects Hyperventilation - physiopathology Laryngeal Larynx - physiopathology Male Medical Education Middle Aged Muscle Strength Dynamometer Pain Measurement - methods Pulmonary/Respiratory Respiration Respiratory Function Tests Rhinitis, Allergic - physiopathology TRPV1 Young Adult |
| Title | Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis |
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