Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis

We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7)...

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Published inRespiratory physiology & neurobiology Vol. 198; pp. 13 - 19
Main Authors Khosravi, Mehdi, Collins, Paul B., Lin, Ruei-Lung, Hayes, Don, Smith, Jaclyn A., Lee, Lu-Yuan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2014
Subjects
Adult
Air
Airway irritation
Airway Resistance
Allergic rhinitis
Carbon Dioxide - metabolism
Cough
Female
Forced Expiratory Volume
Hand Strength
Hot Temperature - adverse effects
Humans
Humidity - adverse effects
Hyperventilation - physiopathology
Laryngeal
Larynx - physiopathology
Male
Medical Education
Middle Aged
Muscle Strength Dynamometer
Pain Measurement - methods
Pulmonary/Respiratory
Respiration
Respiratory Function Tests
Rhinitis, Allergic - physiopathology
TRPV1
Young Adult
Laryngeal
TRPV1
Allergic rhinitis
Cough
Airway irritation
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ISSN1569-9048
1878-1519
1878-1519
DOI10.1016/j.resp.2014.03.013

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Summary:We studied the respiratory responses to an increase in airway temperature in patients with allergic rhinitis (AR). Responses to isocapnic hyperventilation (40% of maximal voluntary ventilation) for 4min of humidified hot air (HA; 49°C) and room air (RA; 21°C) were compared between AR patients (n=7) and healthy subjects (n=6). In AR patients, cough frequency increased pronouncedly from 0.10±0.07 before to 2.37±0.73 during, and 1.80±0.79coughs/min for the first 8min after the HA challenge, but not during the RA challenge. In contrast, neither HA nor RA had any significant tussive effect in healthy subjects. The HA challenge also caused respiratory discomfort (mainly throat irritation) measured by the handgrip dynamometry in AR patients, but not in healthy subjects. Bronchoconstriction was not detected after the HA challenge in either group of subjects. In conclusion, hyperventilation of HA triggered vigorous cough response and throat irritation in AR patients, indicating the involvement of sensory nerves innervating upper airways.
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ISSN:1569-9048
1878-1519
1878-1519
DOI:10.1016/j.resp.2014.03.013