Pathological Characteristics of Domestic Pigs Orally Infected with the Virus Strain Causing the First Reported African Swine Fever Outbreaks in Vietnam

• Published in: Pathogens (Basel) Vol. 12; no. 3; p. 393
• Main Authors: Nguyen, Thi Thu Huyen, Nguyen, Van Tam, Le, Phuong Nam, Mai, Nguyen Tuan Anh, Dong, Van Hieu, Bui, Tran Anh Dao, Nguyen, Thi Lan, Ambagala, Aruna, Le, Van Phan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: African swine fever; ASFV; Causes of; clinical signs; Diagnosis; Disease prevention; DNA viruses; Domestic animals; Epidemics; Epidemiology; Fever; Genes; Genetic aspects; Genomes; Genotype & phenotype; gross findings; Hemorrhage; Hogs; Identification and classification; Inoculation; Lymph nodes; Medical research; Mortality; orally experimental infection; Outbreaks; pathology; Proteins; Swine; Trade restrictions; Vietnam; Viremia; Virulence; Viruses; Vietnam; South Korea; Asia; United States > US; Europe; China; Georgia; orally experimental infection; pathology; ASFV; clinical signs; gross findings
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens12030393

African swine fever (ASF) is currently Vietnam's most economically significant swine disease. The first ASF outbreak in Vietnam was reported in February 2019. In this study, VNUA/HY/ASF1 strain isolated from the first ASF outbreak was used to infect 10 eight-week-old pigs orally with 10 HAD per animal. The pigs were observed daily for clinical signs, and whole blood samples were collected from each animal for viremia detection. Dead pigs were subjected to full post-mortem analyses. All 10 pigs displayed acute or subacute clinical signs and succumbed to the infection between 10 to 27 (19.8 ± 4.66) days post-inoculation (dpi). The onset of clinical signs started around 4-14 dpi. Viremia was observed in pigs from 6-16 dpi (11.2 ± 3.55). Enlarged, hyperemic, and hemorrhagic lymph nodes, enlarged spleen, pneumonia, and hydropericardium were observed at post-mortem examinations.