Bariatric Surgery and Prevention of Type 2 Diabetes in Swedish Obese Subjects

• Published in: The New England journal of medicine Vol. 367; no. 8; pp. 695 - 704
• Main Authors: Carlsson, Lena M.S, Peltonen, Markku, Ahlin, Sofie, Anveden, Åsa, Bouchard, Claude, Carlsson, Björn, Jacobson, Peter, Lönroth, Hans, Maglio, Cristina, Näslund, Ingmar, Pirazzi, Carlo, Romeo, Stefano, Sjöholm, Kajsa, Sjöström, Elisabeth, Wedel, Hans, Svensson, Per-Arne, Sjöström, Lars
• Format: Journal Article Magazine Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 23.08.2012
• Subjects: Adult; Bariatric Surgery; Biological and medical sciences; Body Mass Index; Body weight; Body weight loss; complications; Data processing; Diabetes; Diabetes Mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - prevention & control; epidemiology; Fasting; Fees & charges; Female; Follow-Up Studies; Gastric bypass; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; Gastrointestinal surgery; General aspects; Humans; Incidence; Lifestyles; Male; Medical sciences; Middle Aged; mortality; Nutrition research; Obesity; Obesity - complications; Obesity - surgery; Obesity - therapy; Postoperative Complications; Postoperative Complications - mortality; Postoperative Complications - surgery; Prevention; prevention & control; Prevention and actions; Primary care; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reoperation; Reoperation - statistics & numerical data; Risk Factors; Sensitivity analysis; statistics & numerical data; Stomach, duodenum, intestine, rectum, anus; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; therapy; Type 2; Weight control; Weight Loss; Sweden; Europe; Endocrinopathy; Type 2 diabetes; Human; Medicine; Prevention; Obesity; Nutrition disorder; Bariatric surgery; Metabolic diseases; Nutritional status; Swedish
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa1112082

In this report from the Swedish Obese Subjects study, the rate of incident type 2 diabetes in usual-care and bariatric-surgery groups was 28.4 and 6.8 cases per 1000 person-years, respectively. These findings suggest that surgery is much more efficient than usual care. Multiple studies have shown associations between obesity and type 2 diabetes 1 – 6 and between changes in body weight and incident type 2 diabetes. 7 , 8 It is also well established that the worldwide increase in obesity is associated with an increase in the prevalence of type 2 diabetes. 9 Currently, 285 million people have type 2 diabetes, and this number is predicted to increase to 439 million by 2030. 10 Among persons in a prediabetic state, the incidence of type 2 diabetes is reduced by approximately 40 to 45% with effective lifestyle changes or drug treatment, 11 – 15 and the effects persist, in part, . . .