Beyond the Conventional Description of Dynamic Force Spectroscopy of Adhesion Bonds

Dynamic force spectroscopy of single molecules is described by a model that predicts a distribution of rupture forces, the corresponding mean rupture force, and variance, which are all amenable to experimental tests. The distribution has a pronounced asymmetry, which has recently been observed exper...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 100; no. 20; pp. 11378 - 11381
Main Authors Dudko, O. K., Filippov, A. E., Klafter, J., Urbakh, M.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 30.09.2003
National Acad Sciences
Subjects
Adhesion
Adhesive bonding
Biological Sciences
Biophysics
Chemical bonds
Coordinate systems
Distribution functions
Kinetics
Lead
Mathematical minima
Molecules
Spectroscopy
Spectrum Analysis - methods
Temperature
Velocity
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Summary:Dynamic force spectroscopy of single molecules is described by a model that predicts a distribution of rupture forces, the corresponding mean rupture force, and variance, which are all amenable to experimental tests. The distribution has a pronounced asymmetry, which has recently been observed experimentally. The mean rupture force follows a (lnV)2/3dependence on the pulling velocity, V, and differs from earlier predictions. Interestingly, at low pulling velocities, a rebinding process is obtained whose signature is an intermittent behavior of the spring force, which delays the rupture. An extension to include conformational changes of the adhesion complex is proposed, which leads to the possibility of bimodal distributions of rupture forces.
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To whom correspondence should be addressed. E-mail: urbakh@post.tau.ac.il.
Abbreviation: DFS, dynamic force spectroscopy.
Communicated by Mark A. Ratner, Northwestern University, Evanston, IL, July 21, 2003
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1534554100