Genetic Characterization and Zoonotic Potential of Highly Pathogenic Avian Influenza Virus A(H5N6/H5N5), Germany, 2017-2018

We genetically characterized highly pathogenic avian influenza virus A(H5N6) clade 2.3.4.4b isolates found in Germany in 2017-2018 and assessed pathogenicity of representative H5N5 and H5N6 viruses in ferrets. These viruses had low pathogenicity; however, continued characterization of related isolat...

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Published inEmerging infectious diseases Vol. 25; no. 10; pp. 1973 - 1976
Main Authors Pohlmann, Anne, Hoffmann, Donata, Grund, Christian, Koethe, Susanne, Hüssy, Daniela, Meier, Simone M, King, Jacqueline, Schinköthe, Jan, Ulrich, Reiner, Harder, Timm, Beer, Martin
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.10.2019
Centers for Disease Control and Prevention
Subjects
Analysis
Avian influenza
Avian influenza viruses
Dispatch
Genetic aspects
H5N5
H5N6
H5N8
highly pathogenic avian influenza
HPAI
Influenza
zoonotic potential
Germany
influenza
highly pathogenic avian influenza
reassortment
viruses
epizootic
zoonoses
zoonotic potential
respiratory infections
HPAI
H5N6
H5N5
H5N8
H5Nx
Germany
clade 2.3.4.4b
ferret model
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Summary:We genetically characterized highly pathogenic avian influenza virus A(H5N6) clade 2.3.4.4b isolates found in Germany in 2017-2018 and assessed pathogenicity of representative H5N5 and H5N6 viruses in ferrets. These viruses had low pathogenicity; however, continued characterization of related isolates is warranted because of their high potential for reassortment.
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid2510.181931