Successful treatment of refractory demodicosis and transient papules with a single dose of fluralaner in a dog with uncontrolled severe endocrine disease

A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and...

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Published inJournal of Veterinary Medical Science Vol. 80; no. 4; pp. 672 - 675
Main Authors MORITA, Tatsushi, MOMOTA, Yutaka, MORI, Akihiro, ODA, Hitomi, IKE, Kazunori, SAKO, Toshinori
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.04.2018
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Acaricides - therapeutic use
Adrenocortical Hyperfunction - complications
Adrenocortical Hyperfunction - veterinary
Animals
canine demodicosis
Diabetes
Diabetes mellitus
Dog Diseases - drug therapy
Dog Diseases - parasitology
Dogs
Female
fluralaner
Hypothyroidism
Hypothyroidism - complications
Hypothyroidism - veterinary
Internal Medicine
Isoxazoles - therapeutic use
Mite Infestations - complications
Mite Infestations - drug therapy
Mite Infestations - veterinary
Remission
Skin
transient eruption
transient eruption
canine demodicosis
fluralaner
Online AccessGet full text

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Abstract A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. However, demodicosis went into complete remission with a single dose of fluralaner. Transient erythematous papules appeared on the trunk three days after the administration of fluralaner, but no other adverse reactions were noted. We demonstrated that fluralaner is a potent treatment for demodicosis, and skin eruptions are possible after the first dose of the drug.
AbstractList A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. However, demodicosis went into complete remission with a single dose of fluralaner. Transient erythematous papules appeared on the trunk three days after the administration of fluralaner, but no other adverse reactions were noted. We demonstrated that fluralaner is a potent treatment for demodicosis, and skin eruptions are possible after the first dose of the drug.
A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. However, demodicosis went into complete remission with a single dose of fluralaner. Transient erythematous papules appeared on the trunk three days after the administration of fluralaner, but no other adverse reactions were noted. We demonstrated that fluralaner is a potent treatment for demodicosis, and skin eruptions are possible after the first dose of the drug.A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. However, demodicosis went into complete remission with a single dose of fluralaner. Transient erythematous papules appeared on the trunk three days after the administration of fluralaner, but no other adverse reactions were noted. We demonstrated that fluralaner is a potent treatment for demodicosis, and skin eruptions are possible after the first dose of the drug.
A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. However, demodicosis went into complete remission with a single dose of fluralaner. Transient erythematous papules appeared on the trunk three days after the administration of fluralaner, but no other adverse reactions were noted. We demonstrated that fluralaner is a potent treatment for demodicosis, and skin eruptions are possible after the first dose of the drug.
Author IKE, Kazunori
MORI, Akihiro
ODA, Hitomi
MOMOTA, Yutaka
MORITA, Tatsushi
SAKO, Toshinori
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  fullname: SAKO, Toshinori
  organization: Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan
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Cites_doi 10.1016/j.cvsm.2005.09.003
10.2736/jjvd.10.51
10.1007/s11259-008-9193-0
10.1186/s13071-016-1670-7
10.1111/j.1365-3164.1996.tb00233.x
10.1186/PREACCEPT-2103142870137452
10.1016/j.vetpar.2008.09.009
10.1186/s13071-015-0775-8
10.1046/j.1365-3164.2001.00231.x
10.1111/vde.12453
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Issue 4
Keywords transient eruption
canine demodicosis
fluralaner
Language English
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References 5. Hugnet, C., Bruchon-Hugnet, C., Royer, H. and Bourdoiseau, G. 2001. Efficacy of 1.25% amitraz solution in the treatment of generalized demodicosis (eight cases) and sarcoptic mange (five cases) in dogs. Vet. Dermatol. 12: 89–92.
12. Suzuki, K., Sugimoto, N., Suzuki, H., Higuchi, T., Takahashi, K. and Yuki, M. 2004. Two dogs with uncontrolled generalized demodicosis that improved with doramectin injection. Jpn. J. Vet. Dermatol 10: 51–54.
6. Hutt, J. H. C., Prior, I. C. and Shipstone, M. A. 2015. Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the U.S.A. (2002–2012). Vet. Dermatol. 26: 345–349, e73.
8. Miller, W. H., Griffin, C. E. and Campbell, K. L. 2013. Parasitic skin disease. pp 284–342. In: Muller and Kirk’s Small Animal Dermatology. 7th ed. (Miller W. H., Griffin C. E. and Campbell K. L.). Elsevier, St. Louis.
4. Gortel, K. 2006. Update on canine demodicosis. Vet. Clin. North Am. Small Anim. Pract. 36: 229–241, ix.
9. Mueller, R. S., Bensignor, E., Ferrer, L., Holm, B., Lemarie, S., Paradis, M. and Shipstone, M. A. 2012. Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Vet. Dermatol. 23: 86–96, e20–e21.
10. Rohdich, N., Roepke, R. K. A. and Zschiesche, E. 2014. A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto (fluralaner) against Frontline (fipronil) in flea- and tick-infested dogs. Parasit. Vectors 7: 83.
14. Wengenmayer, C., Williams, H., Zschiesche, E., Moritz, A., Langenstein, J., Roepke, R. K. A. and Heckeroth, A. R. 2014. The speed of kill of fluralaner (Bravecto™) against Ixodes ricinus ticks on dogs. Parasit. Vectors 7: 525.
7. Mealey, K. L. 2008. Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics. Vet. Parasitol. 158: 215–222.
15. Zewe, C. M., Altet, L., Lam, A. T. H. and Ferrer, L. 2017. Afoxolaner and fluralaner treatment do not impact on cutaneous Demodex populations of healthy dogs. Vet. Dermatol. 28: 468–e107.
11. Sako, T., Mori, A., Lee, P., Sato, T., Mizutani, H., Takahashi, T., Kiyosawa, Y., Tazaki, H. and Arai, T. 2009. Serum glycated albumin: Potential use as an index of glycemic control in diabetic dogs. Vet. Res. Commun. 33: 473–479.
2. Fourie, J., Dumont, P., Halos, L., Beugnet, F. and Pollmeier, M. 2013. Efficacy of a topical application of Certifect® (fipronil 6.26% w/v, amitraz 7.48% w/v, (S)-methoprene 5.63% w/v) for the treatment of canine generalized demodicosis. Parasite 20: 46.
3. Fourie, J. J., Liebenberg, J. E., Horak, I. G., Taenzler, J., Heckeroth, A. R. and Frénais, R. 2015. Efficacy of orally administered fluralaner (Bravecto™) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs. Parasit. Vectors 8: 187.
13. Taenzler, J., Liebenberg, J., Roepke, R. K. A., Frénais, R. and Heckeroth, A. R. 2016. Efficacy of fluralaner administered either orally or topically for the treatment of naturally acquired Sarcoptes scabiei var. canis infestation in dogs. Parasit. Vectors 9: 392.
1. Fondati, A. 1996. Efficacy of daily oral ivermectin in the treatment of 10 cases of generalized demodicosis in adult dogs. Vet. Dermatol. 7: 99–104.
11
12
13
14
15
1
2
3
4
5
6
7
8
9
10
References_xml – reference: 5. Hugnet, C., Bruchon-Hugnet, C., Royer, H. and Bourdoiseau, G. 2001. Efficacy of 1.25% amitraz solution in the treatment of generalized demodicosis (eight cases) and sarcoptic mange (five cases) in dogs. Vet. Dermatol. 12: 89–92.
– reference: 9. Mueller, R. S., Bensignor, E., Ferrer, L., Holm, B., Lemarie, S., Paradis, M. and Shipstone, M. A. 2012. Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Vet. Dermatol. 23: 86–96, e20–e21.
– reference: 14. Wengenmayer, C., Williams, H., Zschiesche, E., Moritz, A., Langenstein, J., Roepke, R. K. A. and Heckeroth, A. R. 2014. The speed of kill of fluralaner (Bravecto™) against Ixodes ricinus ticks on dogs. Parasit. Vectors 7: 525.
– reference: 7. Mealey, K. L. 2008. Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics. Vet. Parasitol. 158: 215–222.
– reference: 8. Miller, W. H., Griffin, C. E. and Campbell, K. L. 2013. Parasitic skin disease. pp 284–342. In: Muller and Kirk’s Small Animal Dermatology. 7th ed. (Miller W. H., Griffin C. E. and Campbell K. L.). Elsevier, St. Louis.
– reference: 2. Fourie, J., Dumont, P., Halos, L., Beugnet, F. and Pollmeier, M. 2013. Efficacy of a topical application of Certifect® (fipronil 6.26% w/v, amitraz 7.48% w/v, (S)-methoprene 5.63% w/v) for the treatment of canine generalized demodicosis. Parasite 20: 46.
– reference: 11. Sako, T., Mori, A., Lee, P., Sato, T., Mizutani, H., Takahashi, T., Kiyosawa, Y., Tazaki, H. and Arai, T. 2009. Serum glycated albumin: Potential use as an index of glycemic control in diabetic dogs. Vet. Res. Commun. 33: 473–479.
– reference: 4. Gortel, K. 2006. Update on canine demodicosis. Vet. Clin. North Am. Small Anim. Pract. 36: 229–241, ix.
– reference: 3. Fourie, J. J., Liebenberg, J. E., Horak, I. G., Taenzler, J., Heckeroth, A. R. and Frénais, R. 2015. Efficacy of orally administered fluralaner (Bravecto™) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs. Parasit. Vectors 8: 187.
– reference: 6. Hutt, J. H. C., Prior, I. C. and Shipstone, M. A. 2015. Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the U.S.A. (2002–2012). Vet. Dermatol. 26: 345–349, e73.
– reference: 10. Rohdich, N., Roepke, R. K. A. and Zschiesche, E. 2014. A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto (fluralaner) against Frontline (fipronil) in flea- and tick-infested dogs. Parasit. Vectors 7: 83.
– reference: 1. Fondati, A. 1996. Efficacy of daily oral ivermectin in the treatment of 10 cases of generalized demodicosis in adult dogs. Vet. Dermatol. 7: 99–104.
– reference: 12. Suzuki, K., Sugimoto, N., Suzuki, H., Higuchi, T., Takahashi, K. and Yuki, M. 2004. Two dogs with uncontrolled generalized demodicosis that improved with doramectin injection. Jpn. J. Vet. Dermatol 10: 51–54.
– reference: 13. Taenzler, J., Liebenberg, J., Roepke, R. K. A., Frénais, R. and Heckeroth, A. R. 2016. Efficacy of fluralaner administered either orally or topically for the treatment of naturally acquired Sarcoptes scabiei var. canis infestation in dogs. Parasit. Vectors 9: 392.
– reference: 15. Zewe, C. M., Altet, L., Lam, A. T. H. and Ferrer, L. 2017. Afoxolaner and fluralaner treatment do not impact on cutaneous Demodex populations of healthy dogs. Vet. Dermatol. 28: 468–e107.
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Snippet A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to...
A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to...
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SubjectTerms Acaricides - therapeutic use
Adrenocortical Hyperfunction - complications
Adrenocortical Hyperfunction - veterinary
Animals
canine demodicosis
Diabetes
Diabetes mellitus
Dog Diseases - drug therapy
Dog Diseases - parasitology
Dogs
Female
fluralaner
Hypothyroidism
Hypothyroidism - complications
Hypothyroidism - veterinary
Internal Medicine
Isoxazoles - therapeutic use
Mite Infestations - complications
Mite Infestations - drug therapy
Mite Infestations - veterinary
Remission
Skin
transient eruption
Title Successful treatment of refractory demodicosis and transient papules with a single dose of fluralaner in a dog with uncontrolled severe endocrine disease
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