Successful treatment of refractory demodicosis and transient papules with a single dose of fluralaner in a dog with uncontrolled severe endocrine disease

• Published in: Journal of Veterinary Medical Science Vol. 80; no. 4; pp. 672 - 675
• Main Authors: MORITA, Tatsushi, MOMOTA, Yutaka, MORI, Akihiro, ODA, Hitomi, IKE, Kazunori, SAKO, Toshinori
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.04.2018; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Acaricides - therapeutic use; Adrenocortical Hyperfunction - complications; Adrenocortical Hyperfunction - veterinary; Animals; canine demodicosis; Diabetes; Diabetes mellitus; Dog Diseases - drug therapy; Dog Diseases - parasitology; Dogs; Female; fluralaner; Hypothyroidism; Hypothyroidism - complications; Hypothyroidism - veterinary; Internal Medicine; Isoxazoles - therapeutic use; Mite Infestations - complications; Mite Infestations - drug therapy; Mite Infestations - veterinary; Remission; Skin; transient eruption; transient eruption; canine demodicosis; fluralaner
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.17-0274

A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. However, demodicosis went into complete remission with a single dose of fluralaner. Transient erythematous papules appeared on the trunk three days after the administration of fluralaner, but no other adverse reactions were noted. We demonstrated that fluralaner is a potent treatment for demodicosis, and skin eruptions are possible after the first dose of the drug.