Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological propert...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 12; p. 2934
Main Authors Gu, Yujin, Niu, Qun, Zhang, Qili, Zhao, Yanfang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2024
MDPI
Subjects
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
antidiabetic activity
Antidiabetics
Antioxidants
Antioxidants - pharmacology
Antioxidants - therapeutic use
Bioavailability
Cancer
Catalytic oxidation
curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Cytokines
Development and progression
Diabetes
Diabetes Mellitus, Type 2 - drug therapy
Dietary supplements
Glucose
Humans
Hyperglycemia
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Inflammation
Insulin resistance
Kinases
Lipids
Medical research
Medicine, Botanic
Medicine, Experimental
Medicine, Herbal
Metabolism
Metabolites
molecular mechanisms
Oxidative stress
Pathogenesis
Polyphenols
Proteins
Review
Signal transduction
Toxicity
Tumor necrosis factor-TNF
Type 2 diabetes
type 2 diabetes mellitus
Vitamin deficiency
type 2 diabetes mellitus
molecular mechanisms
antidiabetic activity
curcumin
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Abstract Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, is one of the most studied bioactive components of herbal supplements, and has a variety of biological activities. Clinical trials and preclinical research have recently produced compelling data to demonstrate the crucial functions of curcumin against T2DM via several routes. Accordingly, this review systematically summarizes the antidiabetic activity of curcumin, along with various mechanisms. Results showed that effectiveness of curcumin on T2DM is due to it being anti-inflammatory, anti-oxidant, antihyperglycemic, anti-apoptotic, and antihyperlipidemic, among other activities. In light of these results, curcumin may be a promising prevention/treatment choice for T2DM.
AbstractList Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, is one of the most studied bioactive components of herbal supplements, and has a variety of biological activities. Clinical trials and preclinical research have recently produced compelling data to demonstrate the crucial functions of curcumin against T2DM via several routes. Accordingly, this review systematically summarizes the antidiabetic activity of curcumin, along with various mechanisms. Results showed that effectiveness of curcumin on T2DM is due to it being anti-inflammatory, anti-oxidant, antihyperglycemic, anti-apoptotic, and antihyperlipidemic, among other activities. In light of these results, curcumin may be a promising prevention/treatment choice for T2DM.
Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, is one of the most studied bioactive components of herbal supplements, and has a variety of biological activities. Clinical trials and preclinical research have recently produced compelling data to demonstrate the crucial functions of curcumin against T2DM via several routes. Accordingly, this review systematically summarizes the antidiabetic activity of curcumin, along with various mechanisms. Results showed that effectiveness of curcumin on T2DM is due to it being anti-inflammatory, anti-oxidant, antihyperglycemic, anti-apoptotic, and antihyperlipidemic, among other activities. In light of these results, curcumin may be a promising prevention/treatment choice for T2DM.Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, is one of the most studied bioactive components of herbal supplements, and has a variety of biological activities. Clinical trials and preclinical research have recently produced compelling data to demonstrate the crucial functions of curcumin against T2DM via several routes. Accordingly, this review systematically summarizes the antidiabetic activity of curcumin, along with various mechanisms. Results showed that effectiveness of curcumin on T2DM is due to it being anti-inflammatory, anti-oxidant, antihyperglycemic, anti-apoptotic, and antihyperlipidemic, among other activities. In light of these results, curcumin may be a promising prevention/treatment choice for T2DM.
Audience Academic
Author Niu, Qun
Zhao, Yanfang
Zhang, Qili
Gu, Yujin
AuthorAffiliation 2 Institute of Xinhua Pharmaceutical, Shandong Xinhua Pharmaceutical Co., Ltd., Lutai Avenue 1, Gaoxin District, Zibo 255000, China; junyangniu123@163.com
1 School of Life Sciences and Medicine, Shandong University of Technology, Xincun West Road 266, Zhang Dian District, Zibo 255000, China; guyujin1725@126.com
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Issue 12
Keywords type 2 diabetes mellitus
molecular mechanisms
antidiabetic activity
curcumin
Language English
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Snippet Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that...
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SubjectTerms Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
antidiabetic activity
Antidiabetics
Antioxidants
Antioxidants - pharmacology
Antioxidants - therapeutic use
Bioavailability
Cancer
Catalytic oxidation
curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Cytokines
Development and progression
Diabetes
Diabetes Mellitus, Type 2 - drug therapy
Dietary supplements
Glucose
Humans
Hyperglycemia
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Inflammation
Insulin resistance
Kinases
Lipids
Medical research
Medicine, Botanic
Medicine, Experimental
Medicine, Herbal
Metabolism
Metabolites
molecular mechanisms
Oxidative stress
Pathogenesis
Polyphenols
Proteins
Review
Signal transduction
Toxicity
Tumor necrosis factor-TNF
Type 2 diabetes
type 2 diabetes mellitus
Vitamin deficiency
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Title Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus
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Volume 29
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