Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 12; p. 2934
• Main Authors: Gu, Yujin, Niu, Qun, Zhang, Qili, Zhao, Yanfang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2024; MDPI
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; antidiabetic activity; Antidiabetics; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Bioavailability; Cancer; Catalytic oxidation; curcumin; Curcumin - pharmacology; Curcumin - therapeutic use; Cytokines; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Dietary supplements; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Inflammation; Insulin resistance; Kinases; Lipids; Medical research; Medicine, Botanic; Medicine, Experimental; Medicine, Herbal; Metabolism; Metabolites; molecular mechanisms; Oxidative stress; Pathogenesis; Polyphenols; Proteins; Review; Signal transduction; Toxicity; Tumor necrosis factor-TNF; Type 2 diabetes; type 2 diabetes mellitus; Vitamin deficiency; type 2 diabetes mellitus; molecular mechanisms; antidiabetic activity; curcumin
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29122934

Type 2 diabetes mellitus (T2DM), a multifactorial and complicated metabolic disorder, is a growing public health problem. Numerous studies have indicated that bioactive compounds from herbal medicine have beneficial effects on T2DM prevention and treatment, owing to their numerous biological properties. Curcumin, the major curcuminoid of turmeric, is one of the most studied bioactive components of herbal supplements, and has a variety of biological activities. Clinical trials and preclinical research have recently produced compelling data to demonstrate the crucial functions of curcumin against T2DM via several routes. Accordingly, this review systematically summarizes the antidiabetic activity of curcumin, along with various mechanisms. Results showed that effectiveness of curcumin on T2DM is due to it being anti-inflammatory, anti-oxidant, antihyperglycemic, anti-apoptotic, and antihyperlipidemic, among other activities. In light of these results, curcumin may be a promising prevention/treatment choice for T2DM.