The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

Abstract The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τ w , the threshold R th and optimal R opt radii for particle endocytosis are estimated as a function of the binding energy factor C , bond elasticit...

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Bibliographic Details
Published inBiomaterials Vol. 28; no. 18; pp. 2915 - 2922
Main Authors Decuzzi, P, Ferrari, M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 2007
Subjects
Advanced Basic Science
Algorithms
Bioadhesion
Cell Membrane - metabolism
Dentistry
Drug delivery
Endocytosis
Ligands
Models, Biological
Nanobiotechnology
Nanoparticles
Nanotechnology
Particle internalization
Receptors, Cell Surface - metabolism
Surface Properties
Surface properties
Bioadhesion
Drug delivery
Nanobiotechnology
Particle internalization
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Summary:Abstract The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τ w , the threshold R th and optimal R opt radii for particle endocytosis are estimated as a function of the binding energy factor C , bond elasticity factor G , and non-specific attractive/repulsive factor F at the cell–particle interface. It is shown that the contribution of F is as important as that of C and G . General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.
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ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2007.02.013