3D printed nanocomposite matrix for the study of breast cancer bone metastasis

• Published in: Nanomedicine Vol. 12; no. 1; pp. 69 - 79
• Main Authors: Zhu, Wei, Holmes, Benjamin, Glazer, Robert I., Zhang, Lijie Grace
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2016
• Subjects: 3D printing; Batch Cell Culture Techniques - methods; Biomimetic Materials - chemical synthesis; Bone cancer metastasis; Bone Matrix - chemistry; Bone Neoplasms - pathology; Bone Neoplasms - secondary; Breast cancer; Breast Neoplasms - pathology; Cell Line, Tumor; Humans; Internal Medicine; Materials Testing; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Nanomaterial; Neoplasm Invasiveness; Particle Size; Printing, Three-Dimensional; Tumor Microenvironment; Breast cancer; Nanomaterial; 3D printing; Bone cancer metastasis

Bone is one of the most common metastatic sites of breast cancer, but the underlying mechanisms remain unclear, in part due to an absence of advanced platforms for cancer culture and study that mimic the bone microenvironment. In the present study, we integrated a novel stereolithography-based 3D pr...