Shutoff of RNA Polymerase II Transcription by Poliovirus Involves 3C Protease-Mediated Cleavage of the TATA-Binding Protein at an Alternative Site: Incomplete Shutoff of Transcription Interferes with Efficient Viral Replication

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Published inJournal of Virology Vol. 79; no. 15; pp. 9702 - 9713
Main Authors KUNDU, Pallob, RAYCHAUDHURI, Santanu, TSAI, Weimin, DASGUPTA, Asim
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.2005
Subjects
3C Viral Proteases
Amino Acid Sequence
Biological and medical sciences
Cysteine Endopeptidases - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Viral
Glutamine
HeLa Cells - metabolism
Humans
Microbiology
Miscellaneous
Molecular Sequence Data
Poliovirus - enzymology
Poliovirus - genetics
Poliovirus - physiology
Proteins - genetics
RNA Polymerase II - metabolism
Serine
TATA-Box Binding Protein - genetics
TATA-Box Binding Protein - metabolism
Transcription, Genetic
Viral Proteins - metabolism
Virology
Virus Replication
Virus-Cell Interactions
Microbiology
Transcription
Enzyme
Cysteine endopeptidases
Transferases
Binding site
DNA-directed RNA polymerase
Virology
Peptidases
Binding protein
Nucleotidyltransferases
Hydrolases
Replication
Picornain 3C
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Summary:Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
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Corresponding author. Mailing address: Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, University of California—Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095. Phone: (310) 206-8649. Fax: (310) 206-3865. E-mail: dasgupta@ucla.edu.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.79.15.9702-9713.2005