Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 12; p. 4797
• Main Authors: Li, Jinhua, Wu, Yarong, Dong, Shuze, Yu, Ye, Wu, Yuhao, Xiang, Benhan, Li, Qin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2023; MDPI
• Subjects: Alkaloids; Alkaloids - pharmacology; Alkaloids - therapeutic use; Alzheimer's disease; Analgesics; Analysis; Anesthesia; Angiogenesis; Apoptosis; Autophagy; Brain research; Cell growth; Chinese medicine; Development and progression; Drug dosages; Herbal medicine; Humans; Inflammation; Ischemia; isoquinoline alkaloids; Isoquinolines - pharmacology; mechanism; Metabolic disorders; Morphine; nerve injury; Nervous system; Nervous system diseases; Neurodegeneration; Neurodegenerative Diseases - drug therapy; Neurogenesis; Neurological disorders; Neurons; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Oxidative stress; Parkinson Disease - drug therapy; Parkinson's disease; Pharmacology; Review; Signs and symptoms; China; isoquinoline alkaloids; mechanism; neuroprotection; nerve injury
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28124797

Neuronal injury and apoptosis are important causes of the occurrence and development of many neurodegenerative diseases, such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease. Although the detailed mechanism of some diseases is unknown, the loss of neurons in the brain is still the main pathological feature. By exerting the neuroprotective effects of drugs, it is of great significance to alleviate the symptoms and improve the prognosis of these diseases. Isoquinoline alkaloids are important active ingredients in many traditional Chinese medicines. These substances have a wide range of pharmacological effects and significant activity. Although some studies have suggested that isoquinoline alkaloids may have pharmacological activities for treating neurodegenerative diseases, there is currently a lack of a comprehensive summary regarding their mechanisms and characteristics in neuroprotection. This paper provides a comprehensive review of the active components found in isoquinoline alkaloids that have neuroprotective effects. It thoroughly explains the various mechanisms behind the neuroprotective effects of isoquinoline alkaloids and summarizes their common characteristics. This information can serve as a reference for further research on the neuroprotective effects of isoquinoline alkaloids.