Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 12; p. 4609
• Main Authors: Schoeller, Martin, Piroš, Milan, Litecká, Miroslava, Koňariková, Katarína, Jozefíková, Flóra, Šagátová, Alexandra, Zahradníková, Eva, Valentová, Jindra, Moncol, Ján
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2023; MDPI
• Subjects: Antineoplastic Agents - chemistry; antiproliferative activity; Biological activity; Cancer therapies; Cell cycle; Cell Line, Tumor; Coordination Complexes - chemistry; crystal structure; Crystals; Drugs; Enzymes; Halogens; Heterocyclic Compounds; Hydrogen bonds; Ligands; medicinal inorganic chemistry; Metabolism; Molecular structure; NSAID; Nuclear magnetic resonance spectroscopy; Physiology; Protein Binding; Ruthenium; Ruthenium - chemistry; Ruthenium - pharmacology; Ruthenium(II); salicylate; Salicylates; Spectrum analysis; Structure; Tumors; BSA; salicylate; medicinal inorganic chemistry; DNA; NSAID; crystal structure; Ruthenium(II); anticancer drugs; antiproliferative activity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28124609

Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article. Complexes contain 2,2′-bipyridine molecules and salicylates as ligands, differing in position and type of halogen substituent. The structure of the complexes was determined via X-ray structural analysis and NMR spectroscopy. All complexes were characterized by spectral methods—FTIR, UV–Vis, ESI-MS. Complexes show sufficient stability in solutions. Therefore, their biological properties were studied. Binding ability to BSA, interaction with DNA, as well as in vitro antiproliferative effects against MCF-7 and U-118MG cell lines were investigated. Several complexes showed anticancer effects against these cell lines.