Maternal Experience-Dependent Cortical Plasticity in Mice Is Circuit- and Stimulus-Specific and Requires MECP2

• Published in: The Journal of neuroscience Vol. 40; no. 7; pp. 1514 - 1526
• Main Authors: Lau, Billy Y B, Krishnan, Keerthi, Huang, Z Josh, Shea, Stephen D
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 12.02.2020
• Subjects: Auditory plasticity; Circuits; Cortex (auditory); Disruption; Early experience; Hearing; Interneurons; Maternal behavior; MeCP2 protein; Methyl-CpG binding protein; Mutants; Mutation; Networks; Neural plasticity; Neurodevelopmental disorders; Neuroethology; Neurons; Parvalbumin; Plasticity (neural); Pyramidal cells; Retrieval; Rett syndrome; γ-Aminobutyric acid; Mecp2; plasticity; auditory cortex; neurophysiology; maternal behavior; parvalbumin
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/jneurosci.1964-19.2019

The neurodevelopmental disorder Rett syndrome is caused by mutations in the gene Misexpression of the protein MECP2 is thought to contribute to neuropathology by causing dysregulation of plasticity. Female heterozygous mutants ( ) failed to acquire a learned maternal retrieval behavior when exposed to pups, an effect linked to disruption of parvalbumin-expressing inhibitory interneurons (PV) in the auditory cortex. Nevertheless, how dysregulated PV networks affect the neural activity dynamics that underlie auditory cortical plasticity during early maternal experience is unknown. Here we show that maternal experience in WT adult female mice ( ) triggers suppression of PV auditory responses. We also observe concomitant disinhibition of auditory responses in deep-layer pyramidal neurons that is selective for behaviorally relevant pup vocalizations. These neurons further exhibit sharpened tuning for pup vocalizations following maternal experience. All of these neuronal changes are abolished in , suggesting that they are an essential component of maternal learning. This is further supported by our finding that genetic manipulation of GABAergic networks that restores accurate retrieval behavior in also restores maternal experience-dependent plasticity of PV. Our data are consistent with a growing body of evidence that cortical networks are particularly vulnerable to mutations of in PV neurons. Moreover, our work links, for the first time, impaired cortical plasticity in awake mutant animals to a natural, ethologically relevant behavior. Rett syndrome is a genetic disorder that includes language communication problems. Nearly all Rett syndrome is caused by mutations in the gene that produces the protein MECP2, which is important for changes in brain connectivity believed to underlie learning. We previously showed that female mutants fail to learn a simple maternal care behavior performed in response to their pups' distress cries. This impairment appeared to critically involve inhibitory neurons in the auditory cortex called parvalbumin neurons. Here we record from these neurons before and after maternal experience, and we show that they adapt their response to pup calls during maternal learning in nonmutants, but not in mutants. This adaptation is partially restored by a manipulation that improves learning.