How can Biology of Aging Explain the Severity of COVID-19 in Older Adults

Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarco...

Full description

Saved in:
Bibliographic Details
Published inClinics in geriatric medicine Vol. 38; no. 3; p. 461
Main Authors Gallo, Antonella, Pero, Erika, Pellegrino, Simona, Macerola, Noemi, Murace, Celeste Ambra, Ibba, Francesca, Agnitelli, Maria Chiara, Landi, Francesco, Montalto, Massimo
Format Journal Article
LanguageEnglish
Published United States 01.08.2022
Subjects
Aged
Aging
Biology
COVID-19 - epidemiology
Humans
Immunosenescence
SARS-CoV-2
COVID-19
Sarcopenia
Comorbidities
Aging
Immunosenescence
Inflammaging
Malnutrition
Online AccessGet more information
ISSN1879-8853
DOI10.1016/j.cger.2022.04.002

Cover

Abstract Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.
AbstractList Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.
Author Pero, Erika
Montalto, Massimo
Macerola, Noemi
Ibba, Francesca
Landi, Francesco
Gallo, Antonella
Pellegrino, Simona
Agnitelli, Maria Chiara
Murace, Celeste Ambra
Author_xml – sequence: 1
  givenname: Antonella
  surname: Gallo
  fullname: Gallo, Antonella
  email: antonella.gallo@policlinicogemelli.it
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: antonella.gallo@policlinicogemelli.it
– sequence: 2
  givenname: Erika
  surname: Pero
  fullname: Pero, Erika
  email: pero.erika@gmail.com
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: pero.erika@gmail.com
– sequence: 3
  givenname: Simona
  surname: Pellegrino
  fullname: Pellegrino, Simona
  email: pellegrino.simona3@gmail.com
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: pellegrino.simona3@gmail.com
– sequence: 4
  givenname: Noemi
  surname: Macerola
  fullname: Macerola, Noemi
  email: noemi.macerola@gmail.com
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: noemi.macerola@gmail.com
– sequence: 5
  givenname: Celeste Ambra
  surname: Murace
  fullname: Murace, Celeste Ambra
  email: celeste.murace@gmail.com
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: celeste.murace@gmail.com
– sequence: 6
  givenname: Francesca
  surname: Ibba
  fullname: Ibba, Francesca
  email: franci.ibba@gmail.com
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: franci.ibba@gmail.com
– sequence: 7
  givenname: Maria Chiara
  surname: Agnitelli
  fullname: Agnitelli, Maria Chiara
  email: mariachiaragnitelli@icloud.com
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: mariachiaragnitelli@icloud.com
– sequence: 8
  givenname: Francesco
  surname: Landi
  fullname: Landi, Francesco
  email: francesco.landi@policlinicogemelli.it
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: francesco.landi@policlinicogemelli.it
– sequence: 9
  givenname: Massimo
  surname: Montalto
  fullname: Montalto, Massimo
  email: massimo.montalto@unicatt.it
  organization: Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: massimo.montalto@unicatt.it
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35868666$$D View this record in MEDLINE/PubMed
BookMark eNo1j9tOg0AURSdGYy_6Az6Y-QHwzNAzc3jEWi1JEx68vDY4F6ShQIBq-_cSL087OytZ2XvGzuumdozdCAgFCHW3C03hulCClCEsQgB5xqaCdBwQYTRhs77fAQiEmC7ZJEJSpJSasnTdfHGT1_y-bKqmOPHG86Qo64Kvjm2VlzUfPhx_dp-uK4cfusze0odAxHxkWWVdxxN7qIb-il34vOrd9V_O2evj6mW5DjbZU7pMNoFBJYYAvdUYoTSKUHptUdHYhSZjyHmnzbgRYo1I5JU1ShqPkV5IBUTWCZJzdvvrbQ_ve2e3bVfu8-60_f8kvwHVIEw9
CitedBy_id crossref_primary_10_1080_00918369_2023_2169851
crossref_primary_10_1016_j_jiph_2023_01_016
crossref_primary_10_4110_in_2023_23_e10
crossref_primary_10_1038_s41598_025_85733_5
crossref_primary_10_2196_41404
ContentType Journal Article
Copyright Copyright © 2022 Elsevier Inc. All rights reserved.
Copyright_xml – notice: Copyright © 2022 Elsevier Inc. All rights reserved.
DBID CGR
CUY
CVF
ECM
EIF
NPM
DOI 10.1016/j.cger.2022.04.002
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1879-8853
ExternalDocumentID 35868666
Genre Journal Article
Review
GroupedDBID ---
.1-
.FO
.GJ
0R~
1CY
1P~
29B
34G
39C
4.4
457
53G
5GY
5RE
6J9
6PF
AABSN
AAEDT
AAEDW
AALRI
AAQQT
AAQXK
AAWTL
AAXUO
ABFRF
ABMAC
ABPPZ
ABQZK
ABWVN
ACRPL
ADBBV
ADMUD
ADNMO
AEFWE
AENEX
AEVXI
AFCTW
AFFNX
AFRHN
AFTJW
AI.
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AXIYT
AZFZN
B08
CGR
COIAO
COPKO
CUY
CVF
DAHGL
DU5
EBS
ECM
EIF
EJD
EX3
F5P
FDB
FGOYB
HZ~
LPU
N4W
NPM
O9-
OD~
OO0
R2-
RIG
SEL
SES
TWZ
VH1
WH7
WOW
YCJ
Z5R
ZGI
ZXP
ID FETCH-LOGICAL-c561t-5fd75352c6852f7d568753178cc8efe7c1500975588f6dc62cf537426088de182
IngestDate Thu Jan 02 22:55:10 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords COVID-19
Sarcopenia
Comorbidities
Aging
Immunosenescence
Inflammaging
Malnutrition
Language English
License Copyright © 2022 Elsevier Inc. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c561t-5fd75352c6852f7d568753178cc8efe7c1500975588f6dc62cf537426088de182
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC9023334
PMID 35868666
ParticipantIDs pubmed_primary_35868666
PublicationCentury 2000
PublicationDate 2022-08-01
PublicationDateYYYYMMDD 2022-08-01
PublicationDate_xml – month: 08
  year: 2022
  text: 2022-08-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Clinics in geriatric medicine
PublicationTitleAlternate Clin Geriatr Med
PublicationYear 2022
SSID ssj0015098
Score 2.3527958
SecondaryResourceType review_article
Snippet Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for...
SourceID pubmed
SourceType Index Database
StartPage 461
SubjectTerms Aged
Aging
Biology
COVID-19 - epidemiology
Humans
Immunosenescence
SARS-CoV-2
Title How can Biology of Aging Explain the Severity of COVID-19 in Older Adults
URI https://www.ncbi.nlm.nih.gov/pubmed/35868666
Volume 38
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDI4GCMQF8X6jHLihoG1tGvc43iANDjzEDWVpgngNBOMAvx47SaEaDwGXaoq1tqm_unZif2Zs1eJXJy3AinphrSACLAFZQwtITYqSPHe-N2D7MNs7TQ_O5Xmt9lLJWnruddbN65d1Jf_RKo6hXqlK9g-afT8pDuBv1C8eUcN4_JWOqR8cWbGNyKREXqVvOkSZdTpmMB5bnFeZeHF0tr8lGjmtchxRf-61FvFvPFVd1MAU6tNkL2kSROH_aQt-V8c9mxb1ILahc1G0saFyBg3sTWWQlicer3yf77VjxEf3XdbWBv9yq8Mukr27qi5EYAxbpsHhdyQYT1C5AAjkv6V1TaCCoqRiKtNAwv7JhIfVhOt1Q5SZdB1PRevLsnsVnT7ceaUmEjLIQuOWn6V9tNqlaIANKEUW_ZCWeeL2E3pRECusQjJg_82MspHyBH3xiPdLTsbZWAwoeCugY4LVbHeSDUdETLKRdtTcFNtHuHCEC49Cfu-4hwuPcOEIF17ChaQlXDjKPFx4gMs0O93ZPtncE7GThjDoH_eEdIUiHh-TgWw6VciMwtSGAmPAOqsMzrieKykBXFaYrGmcTBQ1LwAoLIagM2ywi2iaY7xudL2jMEhuaJc6k2pZNLVy5McnTul8ns2Gx3HxEOhSLsoHtfCtZJGNfgBqiQ05fD_tMjp7vc6KV8wbfPJPKg
linkProvider National Library of Medicine
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=How+can+Biology+of+Aging+Explain+the+Severity+of+COVID-19+in+Older+Adults&rft.jtitle=Clinics+in+geriatric+medicine&rft.au=Gallo%2C+Antonella&rft.au=Pero%2C+Erika&rft.au=Pellegrino%2C+Simona&rft.au=Macerola%2C+Noemi&rft.date=2022-08-01&rft.eissn=1879-8853&rft.volume=38&rft.issue=3&rft.spage=461&rft_id=info:doi/10.1016%2Fj.cger.2022.04.002&rft_id=info%3Apmid%2F35868666&rft_id=info%3Apmid%2F35868666&rft.externalDocID=35868666