How can Biology of Aging Explain the Severity of COVID-19 in Older Adults

Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarco...

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Bibliographic Details
Published inClinics in geriatric medicine Vol. 38; no. 3; p. 461
Main Authors Gallo, Antonella, Pero, Erika, Pellegrino, Simona, Macerola, Noemi, Murace, Celeste Ambra, Ibba, Francesca, Agnitelli, Maria Chiara, Landi, Francesco, Montalto, Massimo
Format Journal Article
LanguageEnglish
Published United States 01.08.2022
Subjects
Aged
Aging
Biology
COVID-19 - epidemiology
Humans
Immunosenescence
SARS-CoV-2
COVID-19
Sarcopenia
Comorbidities
Aging
Immunosenescence
Inflammaging
Malnutrition
Online AccessGet more information
ISSN1879-8853
DOI10.1016/j.cger.2022.04.002

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Summary:Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.
ISSN:1879-8853
DOI:10.1016/j.cger.2022.04.002