Erythroleukemia and Gastric Cancer Following Thorotrast Injection

A 63-year-old male, who had undergone angiography using thorium dioxide (Thorotrast) at the age of 15 for investigation of a giant hemangioma on his left thigh, developed anemia in September 1986 (47 yrs after the angiography). A diagnosis of erythroleukemia was made from a bone marrow study which s...

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Bibliographic Details
Published inJapanese Journal of Medicine Vol. 30; no. 1; pp. 43 - 46
Main Authors HIROSE, Yuko, KONDA, Susumu, SASAKI, Keiko, KONISHI, Fumio, TAKAZAKURA, Eisuke
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 1991
Subjects
Adenocarcinoma
Angiography
Autoradiograph
Giant hemangioma
Hemangioma, Cavernous - diagnostic imaging
Hematological malignancy
Humans
Leukemia, Erythroblastic, Acute - etiology
Leukemia, Radiation-Induced - etiology
Male
Middle Aged
Neoplasms, Multiple Primary
Radiography
Skin Neoplasms - pathology
Stomach Neoplasms
Thorium dioxide
Thorium Dioxide - adverse effects
Thorium Dioxide - pharmacokinetics
Tissue Distribution
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Summary:A 63-year-old male, who had undergone angiography using thorium dioxide (Thorotrast) at the age of 15 for investigation of a giant hemangioma on his left thigh, developed anemia in September 1986 (47 yrs after the angiography). A diagnosis of erythroleukemia was made from a bone marrow study which showed 56.4% megaloblastoid erythroblasts and 12.8% myeloblasts. Autopsy revealed Thorotrast deposition in the liver, spleen, bone marrow, and lymph nodes, and monotonous proliferation of myeloblasts in the bone marrow. He also had differentiated tubular adenocarcinoma of the posterior wall of the stomach.
ISSN:0021-5120
1881-123X
DOI:10.2169/internalmedicine1962.30.43