Comparison of eight Lactobacillus species for delivery of surface-displayed mycobacterial antigen

Highlights•AgE6-displaying lactobacilli activate human dendritic cells. •Induction of humoral immunity upon intranasal immunization in mice. •Two of theAgE6-producing lactobacilli induced cellular immunity in mice. •L. plantarum and L. brevis are most promising as tuberculosis vaccine carrier....

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Published inVaccine Vol. 37; no. 43; pp. 6371 - 6379
Main Authors Kuczkowska, Katarzyna, Øverland, Lise, Rocha, Sergio D.C, Eijsink, Vincent G.H, Mathiesen, Geir
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 08.10.2019
Elsevier Limited
Subjects
Allergy and Immunology
Antigens
Bacteria
Cell-mediated immunity
Dendritic cells
Drug delivery systems
ESAT-6 antigen
Food production
Health promotion
Homology
Immune system
Immunization
Immunogenicity
Immunoglobulin A
Immunoglobulin G
Immunomodulation
Inflammation
Interleukin 17
Lactic acid
Lactic acid bacteria
Lactobacilli
Lactobacillus
Lymphocytes
Lymphocytes T
Mucosa
Mucosal immunity
Plasmids
Probiotics
Splenocytes
Strains (organisms)
Tuberculosis
Vaccine
Vaccines
Yogurt
γ-Interferon
Vaccine
Tuberculosis
Immunogenicity
Lactobacillus
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Summary:Highlights•AgE6-displaying lactobacilli activate human dendritic cells. •Induction of humoral immunity upon intranasal immunization in mice. •Two of theAgE6-producing lactobacilli induced cellular immunity in mice. •L. plantarum and L. brevis are most promising as tuberculosis vaccine carrier.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.09.012