Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 5; p. 2303
• Main Authors: Aishajiang, Reyida, Liu, Zhongshan, Wang, Tiejun, Zhou, Liang, Yu, Duo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Angiogenesis; antitumor therapy; Apoptosis; Biological products; Biomaterials; Biomedical materials; Cancer; cancer cell; Care and treatment; Cell death; Cell growth; Copper; Copper - chemistry; copper-associated cell death; copper-based nanomaterials; Energy metabolism; Enzymes; Health aspects; Homeostasis; Humans; Kinases; Lipid metabolism; Lipid peroxidation; Lipids; Nanomaterials; Nanostructures; Nanotechnology; Neoplasms - drug therapy; Oxidation; Oxidative Stress; Physiological aspects; Proteasomes; reactive oxygen species; Reactive Oxygen Species - metabolism; Review; Trace elements; Canada; antitumor therapy; cancer cell; copper-based nanomaterials; copper-associated cell death; reactive oxygen species
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28052303

Copper serves as a vital microelement which is widely present in the biosystem, functioning as multi-enzyme active site, including oxidative stress, lipid oxidation and energy metabolism, where oxidation and reduction characteristics are both beneficial and lethal to cells. Since tumor tissue has a higher demand for copper and is more susceptible to copper homeostasis, copper may modulate cancer cell survival through reactive oxygen species (ROS) excessive accumulation, proteasome inhibition and anti-angiogenesis. Therefore, intracellular copper has attracted great interest that multifunctional copper-based nanomaterials can be exploited in cancer diagnostics and antitumor therapy. Therefore, this review explains the potential mechanisms of copper-associated cell death and investigates the effectiveness of multifunctional copper-based biomaterials in the field of antitumor therapy.