Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs

To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divide...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 80; no. 1; pp. 59 - 62
Main Authors SOMA, Takehisa, SAITO, Namiko, KAWAGUCHI, Masato, SASAI, Kazumi
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2018
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
antibody
Cerebrospinal fluid
Coronaviridae
Coronaviruses
CSF
feline coronavirus
Feline infectious peritonitis
Peritonitis
Polymerase chain reaction
Ribonucleic acid
RNA
RT-PCR
Virology
antibody
feline coronavirus
RT-PCR
CSF
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Summary:To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divided into 2 groups; 15 with CSF titer of 1:80 or lower and 13 with CSF titer of 1:640 or higher. In the latter group, reciprocal serum titer/reciprocal CSF titer was 8 or lower, which is extremely lower than normal range (256-2048), and FCoV RNA was detected in all of 11 CSF samples assayed by RT-PCR. Our findings indicate that CSF titer of 1:640 or higher may be served as a candidate for the index for diagnosing FIP.
Bibliography:ObjectType-Article-1
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ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.17-0399