Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

• Published in: Nature neuroscience Vol. 8; no. 10; pp. 1292 - 1294
• Main Authors: Rondi-Reig, Laure, Burguière, Eric, Arleo, Angelo, Hojjati, Mohammad reza, Elgersma, Ype, Zeeuw, Chris I De, Berthoz, Alain
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.10.2005
• Subjects: Adaptation, Physiological; Adaptation, Physiological - genetics; Adaptation, Physiological - physiology; Analysis of Variance; Animals; Behavior, Animal; Cerebellum; Cerebellum - cytology; Cognitive Sciences; Escape Reaction; Escape Reaction - physiology; Goal-directed behavior; Life Sciences; Long-Term Depression (Physiology); Long-Term Synaptic Depression - physiology; Maze Learning; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Navigation; Neurobiology; Neurons; Neurons and Cognition; Perceptual Disorders; Perceptual Disorders - genetics; Perceptual Disorders - physiopathology; Physiological aspects; Protein Kinase C; Protein Kinase C - genetics; Psychomotor Performance; Psychomotor Performance - physiology; Purkinje Cells; Purkinje Cells - physiology; Reaction Time; Reaction Time - genetics; Spatial Behavior; Spatial Behavior - physiology; Spatial behavior in animals; Spatial learning; Spatial orientation; Time Factors; France
• ISSN: 1097-6256; 1546-1726
• DOI: 10.1038/nn1532

L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions. *Note: In the version of this article initially published online, the third author’s name was incorrect. The correct name is Mohammed reza Hojjati. The error has been corrected in the HTML and print versions of the article.