Diagnostic Significance of Diffusion-Weighted MRI in Renal Cancer

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 12
• Main Authors: Chen, Li-Hua, Liu, Ai-Lian, Sun, Ming-Li, Li, Ye, Ju, Ye, Tian, Shi-Feng, Liu, Jing-Hong, Rao, Yan-Wei, Li, Hai-Feng, Wang, Hong, Lei, Yu, Chen, An-Liang
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc
• Subjects: Accuracy; Adult; Aged; Aged, 80 and over; Cancer; Computer programs; Diagnosis; Diagnosis, Differential; Diffusion; Diffusion Magnetic Resonance Imaging - methods; Electronics; Female; Humans; Image Interpretation, Computer-Assisted; Kidney cancer; Kidney diseases; Kidney Neoplasms - diagnostic imaging; Kidney Neoplasms - pathology; Magnetic resonance imaging; Male; Mathematical analysis; Medical Subject Headings-MeSH; Metabolic disorders; Methods; Middle Aged; Neoplasms - diagnostic imaging; Neoplasms - pathology; NMR; Nuclear magnetic resonance; Patients; Radiography; Software; Studies; Tumors
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2015/172165

Background. This study aimed to investigate whether diffusion-weighted imaging (DWI) could contribute to the discrimination between benign and malignant renal cancer. Methods. We searched the PubMed electronic database for eligible studies. STATA 12.0 software was used for statistical analysis. The SMD and 95% CI were calculated. Results. Decreased ADC signal was seen in all renal cancer patients (cancer tissue versus normal tissue: SMD = 1.63 and 95% CI = 0.96~2.29, P < 0.001 ; cancer tissue versus benign tissue: SMD = 2.22 and 95% CI = 1.53~2.90 and P < 0.001 , resp.). MRI machine type-stratified analysis showed that decreased ADC signal was found by all included MRI machine types in cancer tissues compared with benign cancer tissues (all P < 0.05 ). The ADC values of renal cancer patients were significantly lower than those of normal controls for all included P values (all P < 0.05 ), and there was a decreased ADC signal at b -500, b -600, b -1000, b -500, and 1000 gradients compared with benign cancer tissues (all P < 0.05 ). Conclusion. Our study concluded that decreased ADC signal presented in DWI may be essential for the differential diagnosis of renal cancer.