Biomaterial Hypersensitivity: Is It Real? Supportive Evidence and Approach Considerations for Metal Allergic Patients following Total Knee Arthroplasty

The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient popula...

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Published inBioMed research international Vol. 2015; no. 2015; pp. 1 - 10
Main Authors Saleh, Khaled J., Vasdev, Sonia, Goodman, Stuart B., Dennis, Douglas A., Manning, Blaine T., Grupp, Thomas M., Mihalko, William M., Wilson, Craig J., Mitchelson, Andrew J., Tzeng, Tony H.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2015
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Adult
Aged
Aged, 80 and over
Allergens
Allergic reaction
Allergies
Allergy
Arthroplasty, Replacement, Knee - adverse effects
Arthroplasty, Replacement, Knee - statistics & numerical data
Biocompatible Materials - adverse effects
Biological products
Biomaterials
Biomedical materials
Causation
Complications and side effects
Composition
Dermatitis
Evidence-Based Medicine
Female
Foundations
Humans
Hypersensitivity - epidemiology
Hypersensitivity - etiology
Implants, Artificial
Incidence
Joint replacement surgery
Knees
Male
Metals
Metals - adverse effects
Middle Aged
Orthopedics
Patients
Prosthesis
Review
Risk Factors
Surgical implants
Transplants & implants
Treatment Outcome
Trends
United States > US
Germany
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Summary:The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failure may ultimately be related to metal hypersensitivity. The examination of hypersensitivity reactions in current-generation metal-on-metal knee implants is comparatively limited. The purpose of this study is to summarize all available literature regarding biomaterial hypersensitivity after total knee arthroplasty, elucidate overall trends about this topic in the current literature, and provide a foundation for clinical approach considerations when biomaterial hypersensitivity is suspected.
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Academic Editor: Sandra Utzschneider
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/137287