Cell therapy for diabetic neuropathy using adult stem or progenitor cells
Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterize...
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Published in | Diabetes & metabolism journal Vol. 37; no. 2; pp. 91 - 105 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
Korean Diabetes Association
01.04.2013
대한당뇨병학회 |
Subjects | |
Online Access | Get full text |
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Summary: | Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Ji Woong Han and Min Young Sin contributed equally to this review as first authors. http://www.e-dmj.org/DOIx.php?id=10.4093/dmj.2013.37.2.91 G704-SER000002700.2013.37.2.006 |
ISSN: | 2233-6079 2233-6087 |
DOI: | 10.4093/dmj.2013.37.2.91 |