Synthesis and Structure-Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives

A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive c...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 6; p. 2617
Main Authors Yang, Yazhou, Zhou, Yujie, Jiang, Qiaoju, Tan, Yi, Wu, Wenbin, Han, Ke, Zhu, Rui, Zheng, Shaojun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2023
MDPI
Subjects
Acetonitrile
agrochemicals
Alkaloids
Alkaloids - pharmacology
Antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
Biological activity
Chromatography
cyclotryptamine alkaloids
Environmental impact
Fungi
Fungicides
Molecular Structure
Pesticides
R&D
Research & development
Saline water
SAR
Structure-Activity Relationship
synthesis
cyclotryptamine alkaloids
synthesis
biological activity
SAR
agrochemicals
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Summary:A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive control. Notably, compound displayed the broadest and most effective activity among the tested cyclotryptamine alkaloid derivatives and might be a novel potential leading compound for further development as an antifungal agent.
Bibliography:ObjectType-Article-1
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28062617