Genetic analysis of 18 X-linked short tandem repeat markers in Korean population

• Published in: Forensic science international Vol. 147; no. 1; pp. 35 - 41
• Main Authors: Shin, Sang Hee, Yu, Jin Seok, Park, Sun Wha, Min, Gi Sik, Chung, Ki Wha
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 06.01.2005; Elsevier; The Lancet Publishing Group, a division of Elsevier Science Ltd; Elsevier Limited
• Subjects: Analysis; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Chromosomes; Chromosomes, Human, X; Daughters; DNA Fingerprinting - methods; Families & family life; Female; Females; Forensic genetics; Forensic sciences; Gene Frequency; General aspects; Genetic Markers; Genetics; Genetics, Population; Genomes; Genotype; Haplotype; Haplotypes; Humans; Investigative techniques, diagnostic techniques (general aspects); Korea; Korean; Male; Males; Medical sciences; Mutation; Paternity; Polymorphism; Population genetics; Tandem Repeat Sequences; X chromosome; X-linked STRs; Asia; Korea; Korea, Rep; Korean; Forensic genetics; X-linked STRs; Haplotype; Human; Sex linked character; Forensic science; Biological marker; Biological indicator; Forensic aspect; Genetic disease; Chromosome E18; Analysis; Microsatellite DNA; Genetics; Population; X-Chromosome
• ISSN: 0379-0738; 1872-6283
• DOI: 10.1016/j.forsciint.2004.04.012

The population genetic data of 18 X-chromosomal short tandem repeat (STR) markers DXS6807, DXS8378, DXS9895, DXS9902, DXS6810, DXS7132, DXS981, DXS6800, DXS9898, DXS6789, DXS101, DXS6797, GATA172D05, GATA165B12, HPRTB, GATA31E08, DXS8377, and DXS7423 were analyzed in samples of unrelated 220 males and 181 females from Korean population. The exact test for genotype distribution of the markers showed no significant deviation from the Hardy–Weinberg equilibrium. Allele frequencies between male and female samples were not significantly different in all examined markers. All examined males and females showed different hemizygotic haplotype and combined genotypes, respectively. Four cases of mutation were found in GATA172D05, GATA31E08, DXS7132, and HPRTB from the analysis of 95 father–child–mother trios. Details of X chromosomal STRs in Koreans would be useful in paternity tests and forensic purposes as well as whole X-chromosomal mapping studies.