Synthesis of Hierarchically Porous Bioactive Glass and Its Mineralization Activity

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 5; p. 2224
• Main Authors: Liu, Jiawei, Du, Guo, Yu, Hongda, Zhang, Xueyin, Chen, Tiehong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.02.2023; MDPI
• Subjects: Adsorption; bioactive glass; Biocompatibility; Biocompatible Materials - chemistry; Bioglass; Biological activity; Biomaterials; Biomedical materials; Biomineralization; Block copolymers; Body fluids; Bone biomaterials; Bones; Calcium; Chemical properties; Glass; Glass - chemistry; Health aspects; hierarchically porous structure; Hydroxyapatite; In vitro methods and tests; Materials research; mesoporous material; Mineralization; Morphology; Particle size; Phosphorus; Polyelectrolytes; Pore size; Porosity; Porous materials; Production processes; self-assembly; Silica; Silicon Dioxide; Single crystals; Surfactants; Tissue engineering; Tissue Engineering - methods; China; hierarchically porous structure; hydroxyapatite; self-assembly; bioactive glass; mesoporous material
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28052224

Mesoporous bioactive glass is a promising biomaterial for bone tissue engineering due to its good biocompatibility and bioactivity. In this work, we synthesized a hierarchically porous bioactive glass (HPBG) using polyelectrolyte-surfactant mesomorphous complex as template. Through the interaction with silicate oligomers, calcium and phosphorus sources were successfully introduced into the synthesis of hierarchically porous silica, and HPBG with ordered mesoporous and nanoporous structures was obtained. The morphology, pore structure and particle size of HPBG can be controlled by adding block copolymer as co-template or adjusting the synthesis parameters. The ability to induce hydroxyapatite deposition in simulated body fluids (SBF) demonstrated the good in vitro bioactivity of HPBG. Overall, this work provides a general method for the synthesis of hierarchically porous bioactive glasses.